Prostaglandin E2 receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation

Yi Rang Na; Daun Jung; Michelle Stakenborg; Hyeri Jang; Gyo Jeong Gu; Mi Reu Jeong; Soo Youn Suh; Hak Jae Kim; Yoon Hey Kwon; Tae Sik Sung; Seung Bum Ryoo; Kyu Joo Park; Jong Pil Im; Ji Yong Park; Yun Sang Lee; Heonjong Han; Boyoun Park; Sungwook Lee; Daesik Kim; Ho Su Lee; Isabelle Cleynen; Gianluca Matteoli; Seung Hyeok Seok

doi:10.1136/gutjnl-2020-322146

Article info

Inflammatory bowel disease

Original research

Prostaglandin E₂ receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation

Authors

Yi Rang Na Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea Transdisciplinary Department of Medicine and Advanced Technology, Seoul National University Hospital, Seoul, South Korea PubMed articles Google scholar articles
Daun Jung Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea PubMed articles Google scholar articles
Michelle Stakenborg Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium PubMed articles Google scholar articles
Hyeri Jang Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea PubMed articles Google scholar articles
Gyo Jeong Gu Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea PubMed articles Google scholar articles
Mi Reu Jeong Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea PubMed articles Google scholar articles
Soo Youn Suh Cancer Research Institute, Seoul National University, Seoul, Republic of Korea PubMed articles Google scholar articles
Hak Jae Kim Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea PubMed articles Google scholar articles
Yoon Hey Kwon Department of Surgery, Emergency Medical Center, Seoul National University Hospital, Seoul, Republic of Korea PubMed articles Google scholar articles
Tae Sik Sung Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea PubMed articles Google scholar articles
Seung Bum Ryoo Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea PubMed articles Google scholar articles
Kyu Joo Park Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea PubMed articles Google scholar articles
Jong Pil Im Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea PubMed articles Google scholar articles
Ji Yong Park Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea PubMed articles Google scholar articles
Yun Sang Lee Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea PubMed articles Google scholar articles
Heonjong Han Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea Division of Tumor Immunology, Research Institute, National Cancer Center, Goyang, Republic of Korea PubMed articles Google scholar articles
Boyoun Park Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea PubMed articles Google scholar articles
Sungwook Lee Division of Tumor Immunology, Research Institute, National Cancer Center, Goyang, Republic of Korea PubMed articles Google scholar articles
Daesik Kim Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea PubMed articles Google scholar articles
Ho Su Lee Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Republic of Korea PubMed articles Google scholar articles
Isabelle Cleynen Department of Human Genetics, KU Leuven, Leuven, Belgium PubMed articles Google scholar articles
Gianluca Matteoli Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium PubMed articles Google scholar articles
Seung Hyeok Seok Department of Microbiology and Immunology and Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea PubMed articles Google scholar articles

Correspondence to Prof Gianluca Matteoli, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium; gianluca.matteoli{at}kuleuven.be; Professor Seung Hyeok Seok, Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea; lamseok{at}snu.ac.kr

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Citation

Na YR, Jung D, Stakenborg M, et al

Prostaglandin E₂ receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation

Gut 2021;70:2249-2260.

Publication history

Received June 9, 2020
Revised December 16, 2020
Accepted December 20, 2020
First published February 7, 2021.

Online issue publication

January 08, 2022

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