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A woman aged 30 years was referred for endoscopy for iron deficiency anaemia. Colonoscopy was normal. Upper endoscopy demonstrated multiple small, carpet-like, sessile polyps in the gastric fundus and a larger 4 cm polyp in the body (figure 1). The duodenum was normal without polyps. Endoscopic ultrasound demonstrated a 35×36 mm hypoechoic polypoid lesion arising from the mucosa and invading into the submucosa, but with well-defined borders suggesting lack of invasion into adjacent structures. Endoscopic mucosal resection was performed on a portion of this polyp for histology. Pathology showed a focus of high-grade dysplasia arising in hyperplastic polyp. Her mother and maternal grandmother had gastric cancer, and her sister had gastric polyps and a non-melanoma skin cancer. The patient underwent a laparoscopic total gastrectomy and surgical pathology demonstrated a poorly differentiated adenocarcinoma with 23 negative lymph nodes, stage pT1bN0M0 (figure 2). No adjuvant therapy was recommended, and surveillance CT scan at 6 months was negative. Thirteen months after surgery, she presented with abdominal pain and CT scan showed a 3×4.6 cm hypoattenuating lesion in the left hepatic lobe and a <1 cm lesion in the right lobe. Biopsy demonstrated gastric adenocarcinoma consistent with metastatic disease. Systemic chemotherapy with 5-Fluorouracil, leucovorin, and oxaliplatin (FOLFOX) was initiated. Six months later, both liver lesions remain stable without other sites of disease recurrence.
Genetic testing revealed a mutation in the 1B promoter region of the APC gene (c.191T>C) consistent with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). Hyperplastic and fundic gland polyps commonly occur in the stomach and are usually sporadic and non-neoplastic. However, GAPPS is an extremely rare syndrome with an autosomal dominant inheritance pattern characterised by extensive polyps carpeting the proximal stomach (fundus and body), often clustering with mass-like features, with antral/lesser curvature sparing and no duodenal/colon polyps or extraintestinal manifestations.1 These features distinguish GAPPS from sporadic benign polyps, familial adenomatous polyposis, MUTYH-associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis syndrome and Cowden’s syndrome. GAPPS was first reported in 20122 and has since been identified in <20 families worldwide.3 4 There are no published recommendations on screening for family members, endoscopic surveillance, chemoprevention or timing of prophylactic gastrectomy. There are reported cases of individuals with polyps alone or with early cancer who later present with widespread metastases, similar to our patient, that support prophylactic gastrectomy.5 We share this case to draw attention to GAPPS and call for prospective registries to follow affected families and fill the knowledge gap with clinical guidelines.
We thank Ms Allison Richards, Ms Amanda Gould and their family.
Correction notice This article has been corrected since it published Online First. A typographical error has been corrected in the legend of figure 2.
Contributors Drafting the manuscript: JK, critical revision: SL and SP.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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