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We read with interest the recent study by Yang et al, who reported the construction of three-dimensional bioprinted hepatorganoids (3DP-HOs) using HepaRG cells and bioinks.1 We congratulate the authors for this pioneering study that demonstrates the fabrication and in vivo application of functional 3DP-HOs in mice models of liver failure. The study would pave the way for the use of three-dimensional (3D) bioprinted primary hepatocytes and/or hepatic progenitor cells as possible regenerative therapies in liver diseases. However, there are some caveats in the study, which need to be highlighted.
First, the study showed that after 7 days of differentiation in vitro, HepaRG cells in 3DP-HOs expressed hepatic marker genes and exhibited albumin secretion (figure 2). However, it is to be noted that most …
Contributors SK initiated and wrote the manuscript. DMT gave inputs for the in vivo study. SG highlighted the 3D printing gaps.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Not commissioned; externally peer reviewed.
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