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Reply: Survival in Crohn’s disease-associated small bowel adenocarcinoma
  1. Jordan E Axelrad1,
  2. Ola Olén2,3,4,
  3. Michael C Sachs2,
  4. Rune Erichsen5,6,
  5. Lars Pedersen5,
  6. Jonas Halfvarson7,
  7. Johan Askling2,
  8. Anders Ekbom2,
  9. Henrik Toft Sørensen5,
  10. Jonas F Ludvigsson8,9,10,11
  1. 1 Inflammatory Bowel Disease Center at NYU Langone Health, Division of Gastroenterology, Department of Medicine, New York University School of Medicine, New York, New York, USA
  2. 2 Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
  3. 3 Sachs’ Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden
  4. 4 Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden
  5. 5 Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
  6. 6 Department of Surgery, Randers Regional Hospital, Randers, Denmark
  7. 7 Department of Gastroenterology, Faculty of Medicine and Health, School of Health and Medical Sciences, Örebro University, Örebro, Sweden
  8. 8 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  9. 9 Department of Pediatrics, Orebro University Hospital, Örebro, Sweden
  10. 10 Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK
  11. 11 Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
  1. Correspondence to Jordan E Axelrad, Inflammatory Bowel Disease Center at NYU Langone Health, Division of Gastroenterology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA; Jordan.Axelrad{at}

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The authors would like to thank Giuffrida and colleagues for their interest in our manuscript, ‘Inflammatory Bowel Disease and Risk of Small Bowel Cancer: A binational population-based cohort study from Denmark and Sweden’.1 2 In contrast to previous studies focused on small bowel adenocarcinoma death with short follow-up time, we provide an age-adjusted composite risk of death due to multiple small bowel cancer subtypes, including adenocarcinoma, neuroendocrine tumours and sarcoma, with over 20 years of follow-up.3–6 We adjusted for cancer heredity and in sensitivity analyses, excluded patients with coeliac disease …

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  • JEA and OO contributed equally.

  • Contributors All authors contributed in the design of the paper and approved the final version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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