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We thank Kaur et al 1 for their valuable comments on our three-dimensional bioprinted hepatorganoids (3DP-HO) published in Gut.2 We have read with care all the concerns raised by Kaur et al 1 and acknowledge the great contributions of Ghosh et al 3 to the field of 3D in vitro tumour cell cultures. We would like to discuss the issues in detail as below.
First, this study showed that after 7 days of differentiation in vitro, HepaRG cells in 3DP-HOs expressed hepatic marker genes and exhibited albumin secretion (figure 2). The relevant experimental methods were described in detail in the supplementary …
Contributors HY, LS and YM wrote the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.