Footnotes

• Twitter @CUBEROlab

• Contributors FJC drafted and wrote the commentary.

• Funding The MINECO Retos SAF2016-78711, EXOHEP-CM S2017/BMD-3727, NanoLiver-CM Y2018/NMT-4949, ERAB Ref. EA 18/14, AMMF 2018/117, COST Action CA17112 and UCM-25/2019. FJC is a Ramón y Cajal Researchers RYC-2014–15242 and a Gilead Liver Research Scholar 2018. The research group belongs to the validated Research Groups Ref. 970935 “Liver Pathophysiology” and 920631 'Lymphocyte immunobiology' and IBL-6 (imas12-associated).

• Competing interests None declared.

• Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this research.

• Provenance and peer review Commissioned; internally peer reviewed.