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Time series analysis of microbiome and metabolome at multiple body sites in steady long-term isolation confinement

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  • QF, XL, XJ, ML and SL are joint first authors.

  • QF, XL, XJ, ML and SL contributed equally.

  • Contributors FQ, LX, JXL, LMH, LSL contributed equally to this paper.FQ and LYH designed and conducted the experiments. XJH, YYB, LZP, XZ, HL, CY, DHS, CP, CB conducted the experiment. LX, LMH analysed the data. JXL, LSL, HKL, FQ and LYH edited the manuscript.

  • Funding This study was supported by the National Natural Science Foundation of China (No. 81630072), The Fundamental Research Funds of Shandong University (2015JC010), Programme of Qilu young scholars of Shandong University (sdxz201699000032), the constructional engineering Special Found of Taishan Scholar programme (tsqn20190918). We would like to express special thankfulness to the Development and Reform Commission of Shenzhen Municipality for sponsoring the 4-person-180-day CELSS integrated experiment, and funds from Shenzhen Science & Technology Programme (JCYJ20151029154245758, CKFW2016082915204709). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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