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Letter
Modulating immunosuppression in liver transplant patients with COVID-19
  1. Manuel Rodriguez-Peralvarez1,2,3,
  2. Magdalena Salcedo3,4,
  3. Jordi Colmenero3,5,
  4. Jose Antonio Pons6
  1. 1 Hepatology and Liver Transplantation, Reina Sofia University Hospital, Cordoba, Andalucía, Spain
  2. 2 Grupo G02, Maimonides Institute of Biomedical Research of Córdoba (IMIBIC), Córdoba, Spain
  3. 3 CIBEREHD, Madrid, Madrid, Spain
  4. 4 Hepatology, Hospital General Universitario Gregorio Marañón, Madrid, Madrid, Spain
  5. 5 Hepatology and Liver Transplantation, Hospital Clinic, Barcelona, Catalunya, Spain
  6. 6 Virgen de la Arrixaca University Hospital, El Palmar, Murcia, Spain
  1. Correspondence to Dr Manuel Rodriguez-Peralvarez, Hepatology and Liver Transplantation, Reina Sofia University Hospital, Cordoba, Andalucía, Spain; ropeml{at}hotmail.com

http://dx.doi.org/10.1136/gutjnl-2020-322620

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    We read with great interest the COVID-LT study by C Becchetti et al,1 which included 57 liver transplant (LT) patients from 12 European institutions who were diagnosed with coronavirus disease 2019 (COVID-19). Simultaneously, the Spanish Society of Liver Transplantation (SETH) has conducted a nationwide prospective study including 22 transplant institutions and 111 LT patients with COVID-19.2 Since there were only nine overlapped cases, both cohorts add up to 159 LT patients and taken together their close analysis (table 1) may derive in practical conclusions.

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    Table 1

    Clinical characteristics and outcomes of LT patients included in the European COVID-LT cohort and in the nationwide study from the Spanish Society of Liver Transplantation (SETH)

    The crude incidence of COVID-19 was increased in the SETH study as compared with the COVID-LT study (0.84% vs 0.48%), even with a shorter recruitment period. This could be explained because the SETH study was performed during the outbreak period in Spain, one of the toughest in Europe.3 The SETH study …

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    Footnotes

    • Contributors MRP drafted the manuscript; MS, JC and JAP critically reviewed the manuscript for important intellectual content. All authors have approved the final version of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Not commissioned; externally peer reviewed.