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Role of Helicobacter pylori in gastric diseases pathogenesis cannot be ignored
  1. Xianzhu Zhou,
  2. Huiyun Zhu,
  3. Yan Chen,
  4. Zhaoshen Li,
  5. Yiqi Du
  1. Department of Gastroenterology, Changhai Hospital, Shanghai, China
  1. Correspondence to Professor Yiqi Du, Department of Gastroenterology, Changhai Hospital, Shanghai 200433, China; duyiqi006{at}

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We read with interest the study by Guo et al, evaluating the risk of gastrointestinal bleeding (GIB) in aspirin users after Helicobacter pylori eradication.1 It revealed a higher risk of GIB in new aspirin users even after H. pylori eradication than chronic aspirin users as well as non-users. The propensity score matching method was also performed to balance the potential differences of baseline characteristics among groups, which largely compensate for the deficiencies of retrospective research. However, the prevalence of H. pylori infection among Chinese population remains high (40%–60%).2 3 We hope to explicitly demonstrate the relationship between H. pylori infection and gastric diseases to justify the necessity of H. pylori eradication.

In our recent retrospective study, …

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  • Contributors YD and ZL conceived and designed the study, XZ, HZ and YC wrote the draft. All authors final approval of the letter. XZ, HZ and YC contributed equally.

  • Funding This investigation was supported by the grant from National Clinical Research Center for Digestive Diseases of China (2015BAI13B08). HZ is supported by Youth Start-up Fund of Changhai Hospital (Grant No. 2019QNA01). YD is supported by Shanghai Health Commission advanced appropriate technology promotion project (2019SY001).

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

  • Provenance and peer review Not commissioned; internally peer reviewed.