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  • Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells

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Coeliac disease
Original research
Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells

Authors

  • Ane Olazagoitia-Garmendia Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV-EHU), Leioa, Spain Biocruces Bizkaia Health Research Institute, Barakaldo, Spain PubMed articlesGoogle scholar articles
  • Linda Zhang Department of Chemistry, Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, USA PubMed articlesGoogle scholar articles
  • Paula Mera Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain PubMed articlesGoogle scholar articles
  • Julie K Godbout Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada PubMed articlesGoogle scholar articles
  • Maialen Sebastian-DelaCruz Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV-EHU), Leioa, Spain Biocruces Bizkaia Health Research Institute, Barakaldo, Spain PubMed articlesGoogle scholar articles
  • Iraia Garcia-Santisteban Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV-EHU), Leioa, Spain PubMed articlesGoogle scholar articles
  • Luis Manuel Mendoza Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV-EHU), Leioa, Spain PubMed articlesGoogle scholar articles
  • Alain Huerta Enfermedades Digestivas, Hospital de Galdakao-Usansolo, Galdacano, Spain PubMed articlesGoogle scholar articles
  • Iñaki Irastorza Department of Pediatrics, University of the Basque Country (UPV-EHU), Leioa, Spain PubMed articlesGoogle scholar articles
  • Govind Bhagat Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York, NY, USA PubMed articlesGoogle scholar articles
  • Peter H Green Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York, NY, USA PubMed articlesGoogle scholar articles
  • Laura Herrero Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain PubMed articlesGoogle scholar articles
  • Dolors Serra Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain PubMed articlesGoogle scholar articles
  • Jose Antonio Rodriguez Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV-EHU), Leioa, Spain PubMed articlesGoogle scholar articles
  • Elena F Verdu Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada PubMed articlesGoogle scholar articles
  • Chuan He Department of Chemistry, Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, USA PubMed articlesGoogle scholar articles
  • Jose Ramon Bilbao Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV-EHU), Leioa, Spain Biocruces Bizkaia Health Research Institute, Barakaldo, Spain CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain PubMed articlesGoogle scholar articles
  • Ainara Castellanos-Rubio Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV-EHU), Leioa, Spain Biocruces Bizkaia Health Research Institute, Barakaldo, Spain CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain Ikerbasque, Basque Foundation for Science, Bilbao, Spain PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Ainara Castellanos-Rubio, Genetics, Physical Anthropology and Animal Physiology, Universidad del Pais Vasco, Leioa 48940, Spain; ainara.castellanos{at}ehu.eus
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Citation

Olazagoitia-Garmendia A, Zhang L, Mera P, et al
Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells
Gut 2022;71:68-76.

Publication history

  • Received July 20, 2020
  • Revised December 23, 2020
  • Accepted January 17, 2021
  • First published February 1, 2021.
Online issue publication 
February 02, 2022

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.