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Original research
CXCR2 inhibition enables NASH-HCC immunotherapy

Authors

  • Jack Leslie Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  • John B G Mackey Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Thomas Jamieson Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Erik Ramon-Gil Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  • Thomas M Drake Cancer Research UK Beatson Institute, Glasgow, UK MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK Institute of Cancer Sciences, University of Glasgow, Glasgow, UK PubMed articlesGoogle scholar articles
  • Frédéric Fercoq Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • William Clark Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Kathryn Gilroy Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Ann Hedley Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Colin Nixon Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Saimir Luli Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK Preclinical In Vivo Imaging Facility, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  • Maja Laszczewska Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  • Roser Pinyol Translational Research in Hepatic Oncology, Liver Unit, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Roger Esteban-Fabró Translational Research in Hepatic Oncology, Liver Unit, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Spain Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Catherine E Willoughby Translational Research in Hepatic Oncology, Liver Unit, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Philipp K Haber Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Carmen Andreu-Oller Translational Research in Hepatic Oncology, Liver Unit, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Spain Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Mohammad Rahbari Division of Chronic Inflammation and Cancer, German Cancer Research Centre, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Chaofan Fan Division of Chronic Inflammation and Cancer, German Cancer Research Centre, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Dominik Pfister Division of Chronic Inflammation and Cancer, German Cancer Research Centre, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Shreya Raman Department of Pathology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK PubMed articlesGoogle scholar articles
  • Niall Wilson Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  • Miryam Müller Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Amy Collins Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  • Daniel Geh Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  • Andrew Fuller Flow Cytometry Facility, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK PubMed articlesGoogle scholar articles
  • David McDonald Flow Cytometry Facility, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK PubMed articlesGoogle scholar articles
  • Gillian Hulme Flow Cytometry Facility, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK PubMed articlesGoogle scholar articles
  • Andrew Filby Flow Cytometry Facility, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK Innovation, Methodology and Innovation (IMA) theme, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  • Xabier Cortes-Lavaud Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Noha-Ehssan Mohamed Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Catriona A Ford Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Ximena L Raffo Iraolagoitia Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Amanda J McFarlane Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Misti V McCain The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  • Rachel A Ridgway Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Edward W Roberts Cancer Research UK Beatson Institute, Glasgow, UK PubMed articlesGoogle scholar articles
  • Simon T Barry Bioscience, Early Oncology, AstraZeneca, Macclesfield, UK PubMed articlesGoogle scholar articles
  • Gerard J Graham Chemokine Research Group, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK PubMed articlesGoogle scholar articles
  • Mathias Heikenwälder Division of Chronic Inflammation and Cancer, German Cancer Research Centre, Heidelberg, Germany Department of Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Helen L Reeves The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  • Josep M Llovet Translational Research in Hepatic Oncology, Liver Unit, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Spain Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain PubMed articlesGoogle scholar articles
  • Leo M Carlin Cancer Research UK Beatson Institute, Glasgow, UK Institute of Cancer Sciences, University of Glasgow, Glasgow, UK PubMed articlesGoogle scholar articles
  • Thomas G Bird Cancer Research UK Beatson Institute, Glasgow, UK MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Owen J Sansom Cancer Research UK Beatson Institute, Glasgow, UK Institute of Cancer Sciences, University of Glasgow, Glasgow, UK Beatson Institute for Cancer Research, Glasgow, UK PubMed articlesGoogle scholar articles
  • Derek A Mann Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK Fibrofind Ltd, William Leech Building, Medical School, Newcastle University, Newcastle upon Tyne, UK Department of Gastroenterology and Hepatology, School of Medicine, Koç University, Istanbul, Turkey PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Derek A Mann, Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, Newcastle upon Tyne, UK; derek.mann{at}newcastle.ac.uk
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Citation

Leslie J, Mackey JBG, Jamieson T, et al
CXCR2 inhibition enables NASH-HCC immunotherapy

Publication history

  • Received October 5, 2021
  • Accepted March 17, 2022
  • First published April 27, 2022.
Online issue publication 
May 04, 2023

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