Footnotes

• Contributors TB-M, AK and ET conceived the ideas and designed the paper. AK and ET were involved in critical revision of the manuscript. All authors contributed to and approved the final manuscript.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests AK is a consultant for Jinshan. He is director of iCERV Ltd and cofounder of AJM Medicaps Ltd. He has received a GivenImaging Ltd-ESGE grant, and material support for clinical research from SynMed/Intromedic. In the last 10 years, he has received honoraria and lecture fees from Jinshan, Dr FalkPharma UK and Ferring. He has also received educational travel support from Aquilant, Jinshan, Dr FalkPharma, Almirall, Ferring, and has participated in advisory board meetings for Tillots, Ankon, and Dr FalkPharmaUK. ET has received a research grant from the Swedish Cancer Society and the Swedish ALF agreement.

• Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

• Provenance and peer review Not commissioned; internally peer reviewed.