Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis

Moritz Leppkes; Aylin Lindemann; Stefanie Gößwein; Susanne Paulus; Dominik Roth; Anne Hartung; Eva Liebing; Sebastian Zundler; Miguel Gonzalez-Acera; Jay V Patankar; Fabrizio Mascia; Kristina Scheibe; Markus Hoffmann; Stefan Uderhardt; Christine Schauer; Sebastian Foersch; Clemens Neufert; Michael Vieth; Georg Schett; Raja Atreya; Anja A Kühl; Andre Bleich; Christoph Becker; Martin Herrmann; Markus F Neurath

doi:10.1136/gutjnl-2021-324725

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Inflammatory bowel disease

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Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis

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Moritz Leppkes Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany Deutsches Zentrum Immuntherapie, Erlangen, Germany PubMed articles Google scholar articles
Aylin Lindemann Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Stefanie Gößwein Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Susanne Paulus Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Dominik Roth Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Anne Hartung Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Eva Liebing Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Sebastian Zundler Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany Deutsches Zentrum Immuntherapie, Erlangen, Germany PubMed articles Google scholar articles
Miguel Gonzalez-Acera Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Jay V Patankar Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Fabrizio Mascia Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Kristina Scheibe Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Markus Hoffmann Medical Clinic 3, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Stefan Uderhardt Deutsches Zentrum Immuntherapie, Erlangen, Germany Medical Clinic 3, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Christine Schauer Medical Clinic 3, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Sebastian Foersch Institute of Pathology, University Medical Center, Mainz, Germany PubMed articles Google scholar articles
Clemens Neufert Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany Deutsches Zentrum Immuntherapie, Erlangen, Germany PubMed articles Google scholar articles
Michael Vieth Friedrich Alexander University, Institute of Pathology, Klinikum Bayreuth, Erlangen, Germany PubMed articles Google scholar articles
Georg Schett Deutsches Zentrum Immuntherapie, Erlangen, Germany Medical Clinic 3, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Raja Atreya Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany Deutsches Zentrum Immuntherapie, Erlangen, Germany PubMed articles Google scholar articles
Anja A Kühl Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany PubMed articles Google scholar articles
Andre Bleich Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany PubMed articles Google scholar articles
Christoph Becker Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Martin Herrmann Medical Clinic 3, University Clinic, Friedrich Alexander University, Erlangen, Germany PubMed articles Google scholar articles
Markus F Neurath Medical Clinic 1, University Clinic, Friedrich Alexander University, Erlangen, Germany Deutsches Zentrum Immuntherapie, Erlangen, Germany PubMed articles Google scholar articles

Correspondence to Dr Moritz Leppkes, Department of Medicine 1, University Clinic, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany; moritz.leppkes{at}uk-erlangen.de

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Leppkes M, Lindemann A, Gößwein S, et al

Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis

Gut 2022;71:2414-2429.

Publication history

Received March 22, 2021
Accepted November 2, 2021
First published December 3, 2021.

Online issue publication

May 11, 2023

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This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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