Gut mucosa alterations and loss of segmented filamentous bacteria in type 1 diabetes are associated with inflammation rather than hyperglycaemia

Matthieu Rouland; Lucie Beaudoin; Ophélie Rouxel; Léo Bertrand; Lucie Cagninacci; Azadeh Saffarian; Thierry Pedron; Dalale Gueddouri; Sandra Guilmeau; Anne-Françoise Burnol; Latif Rachdi; Asmaa Tazi; Juliette Mouriès; Maria Rescigno; Nathalie Vergnolle; Philippe Sansonetti; Ute Christine Rogner; Agnès Lehuen

doi:10.1136/gutjnl-2020-323664

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Gut microbiota

Original research

Gut mucosa alterations and loss of segmented filamentous bacteria in type 1 diabetes are associated with inflammation rather than hyperglycaemia

Authors

Matthieu Rouland Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France Laboratoire d'Excellence Inflamex, Université de Paris, Paris, France PubMed articles Google scholar articles
Lucie Beaudoin Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France Laboratoire d'Excellence Inflamex, Université de Paris, Paris, France PubMed articles Google scholar articles
Ophélie Rouxel Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France Laboratoire d'Excellence Inflamex, Université de Paris, Paris, France PubMed articles Google scholar articles
Léo Bertrand Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France Laboratoire d'Excellence Inflamex, Université de Paris, Paris, France PubMed articles Google scholar articles
Lucie Cagninacci Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France Laboratoire d'Excellence Inflamex, Université de Paris, Paris, France PubMed articles Google scholar articles
Azadeh Saffarian Institut Pasteur, INSERM U1202, Paris, France PubMed articles Google scholar articles
Thierry Pedron Institut Pasteur, INSERM U1202, Paris, France PubMed articles Google scholar articles
Dalale Gueddouri Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France PubMed articles Google scholar articles
Sandra Guilmeau Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France PubMed articles Google scholar articles
Anne-Françoise Burnol Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France PubMed articles Google scholar articles
Latif Rachdi Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France PubMed articles Google scholar articles
Asmaa Tazi Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France PubMed articles Google scholar articles
Juliette Mouriès Department of Biomedical Sciences - IRCCS, Via Rita Levi Montalcini, 20090 Pieve Emanuele, Humanitas University, Milan, Italy IRCCS, Via Manzoni 56, 20089 Rozzano, Humanitas Clinical and Research Center, Milan, Italy PubMed articles Google scholar articles
Maria Rescigno Department of Biomedical Sciences - IRCCS, Via Rita Levi Montalcini, 20090 Pieve Emanuele, Humanitas University, Milan, Italy IRCCS, Via Manzoni 56, 20089 Rozzano, Humanitas Clinical and Research Center, Milan, Italy PubMed articles Google scholar articles
Nathalie Vergnolle Université de Toulouse, Institut de Recherche en Santé Digestive, INSERM U1220, INRAE, ENVT, Toulouse, France PubMed articles Google scholar articles
Philippe Sansonetti Institut Pasteur, INSERM U1202, Paris, France PubMed articles Google scholar articles
Ute Christine Rogner Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France Laboratoire d'Excellence Inflamex, Université de Paris, Paris, France PubMed articles Google scholar articles
Agnès Lehuen Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France Laboratoire d'Excellence Inflamex, Université de Paris, Paris, France PubMed articles Google scholar articles

Correspondence to Professor Agnès Lehuen, Institut Cochin, Université de Paris, CNRS UMR 8104 and INSERM U1016, 123 Boulevard de Port-Royal, Paris 75014, France; agnes.lehuen{at}inserm.fr

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Citation

Rouland M, Beaudoin L, Rouxel O, et al

Gut mucosa alterations and loss of segmented filamentous bacteria in type 1 diabetes are associated with inflammation rather than hyperglycaemia

Gut 2022;71:296-308.

Publication history

Received November 19, 2020
Revised February 1, 2021
Accepted February 2, 2021
First published February 16, 2021.

Online issue publication

May 11, 2022

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