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Colon capsule endoscopy: the evidence is piling up
  1. George Koulaouzidis1,
  2. Alexander Robertson2,
  3. Hagen Wenzek3,
  4. Anastasios Koulaouzidis1
  1. 1 Pomeranian Medical University, Szczecin, Poland
  2. 2 Western General Hospital, Edinburgh, UK
  3. 3 Corporate Health International, Odense, Denmark
  1. Correspondence to Dr Anastasios Koulaouzidis, Department of Social Medicine & Public Health, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Szczecin, Zachodniopomorskie, Poland; akoulaouzidis{at}

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We read with interest the multicentre comparison study by Cash et al on the diagnostic yield (DY) of colon capsule endoscopy (CCE) versus CT colonography (CTC) in a screening population.1 Out of 320 enrolled, data from 286 (89.4%) subjects were evaluated. CCE was superior to CTC in the detection of polyps ≥6 mm and non-inferior for polyps ≥10 mm. A recent meta-analysis2 of the use of CCE and CTC in patients with incomplete optical colonoscopy (OC) showed the DY of CTC at 10% (95% CI 7%–15%) and of CCE at 37% (95% CI 30%–43%) for any size polyp, suggesting the increased DY of CCE could outweigh its lower completion rate compared with the superiority of CTC there. Furthermore, a recent systematic review,3 including 2485 patients across 13 studies, confirmed that CCE is highly sensitive for …

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