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Intestinal inflammation
Immunoglobulin A–specific deficiency induces spontaneous inflammation specifically in the ileum

Authors

  • Takashi Nagaishi Department of Gastroenterology and Hepatology, Graduate School of Medical Science, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan Department of Advanced Therapeutics for GI Diseases, Graduate School of Medical Science, TMDU, Bunkyo-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Taro Watabe Department of Gastroenterology and Hepatology, Graduate School of Medical Science, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Kunihiko Kotake Department of Immunology, Medical Research Institute, TMDU, Bunkyo-ku, Tokyo, Japan Research and Development Department, Ichibiki Co., Ltd, Nagoya, Aichi, Japan PubMed articlesGoogle scholar articles
  • Toshihiko Kumazawa Department of Immunology, Medical Research Institute, TMDU, Bunkyo-ku, Tokyo, Japan Research and Development Department, Ichibiki Co., Ltd, Nagoya, Aichi, Japan PubMed articlesGoogle scholar articles
  • Tomomi Aida Department of Molecular Neuroscience, Medical Research Institute, TMDU, Bunkyo-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Kohichi Tanaka Department of Molecular Neuroscience, Medical Research Institute, TMDU, Bunkyo-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Ryuichi Ono Department of Epigenetics, Medical Research Institute, TMDU, Bunkyo-ku, Tokyo, Japan Current address: Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences (NIHS), Kawasaki, Kanagawa, Japan PubMed articlesGoogle scholar articles
  • Fumitoshi Ishino Department of Epigenetics, Medical Research Institute, TMDU, Bunkyo-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Takako Usami Laboratory of Recombinant Animals, Medical Research Institute, TMDU, Bunkyo-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Takamasa Miura Biological Resource Center, National Institute of Technology and Evaluation (NITE), Shibuya-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Satomi Hirakata Biological Resource Center, National Institute of Technology and Evaluation (NITE), Shibuya-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Hiroko Kawasaki Biological Resource Center, National Institute of Technology and Evaluation (NITE), Shibuya-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Naoya Tsugawa Department of Gastroenterology and Hepatology, Graduate School of Medical Science, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Daiki Yamada Department of Gastroenterology and Hepatology, Graduate School of Medical Science, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Kazuhiro Hirayama Laboratory of Veterinary Public Health, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Soichiro Yoshikawa Department of Immune Regulation, Graduate School of Medical Science, TMDU, Bunkyo-ku, Tokyo, Japan Current address: Department of Cellular Physiology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Kita-ku, Okayama, Japan PubMed articlesGoogle scholar articles
  • Hajime Karasuyama Department of Immune Regulation, Graduate School of Medical Science, TMDU, Bunkyo-ku, Tokyo, Japan Advanced Research Institute, TMDU, Bunkyo-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Ryuichi Okamoto Department of Gastroenterology and Hepatology, Graduate School of Medical Science, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Mamoru Watanabe Department of Gastroenterology and Hepatology, Graduate School of Medical Science, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan Advanced Research Institute, TMDU, Bunkyo-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Richard S Blumberg Gastroenterology Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Takahiro Adachi Department of Immunology, Medical Research Institute, TMDU, Bunkyo-ku, Tokyo, Japan Current address: Department of Precision Health, Medical Research Institute, TMDU, Chiyoda-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  1. Correspondence to Associate Professor Takahiro Adachi, Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan; tadachi.imm{at}mri.tmd.ac.jp; Associate Professor Takashi Nagaishi, Department of Advanced Therapeutics for GI Diseases, Graduate School of Medical Science, TMDU, Bunkyo-ku, Tokyo, Japan; tnagaishi.gast{at}tmd.ac.jp; Professor Richard S Blumberg, Gastroenterology Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; rblumberg{at}bwh.harvard.edu
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Citation

Nagaishi T, Watabe T, Kotake K, et al
Immunoglobulin A–specific deficiency induces spontaneous inflammation specifically in the ileum
Gut 2022;71:487-496.

Publication history

  • Received August 22, 2020
  • Revised April 2, 2021
  • Accepted April 21, 2021
  • First published May 7, 2021.
Online issue publication 
May 11, 2022

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