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Gut microbiota
Original research
Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies

Authors

  • Qibin Qi Department of Epidemiology and Population Health, Yeshiva University Albert Einstein College of Medicine, Bronx, New York, USA Department of Nutrtion, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Jun Li Department of Nutrtion, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA Department of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Bing Yu Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Jee-Young Moon Department of Epidemiology and Population Health, Yeshiva University Albert Einstein College of Medicine, Bronx, New York, USA PubMed articlesGoogle scholar articles
  • Jin C Chai Department of Epidemiology and Population Health, Yeshiva University Albert Einstein College of Medicine, Bronx, New York, USA PubMed articlesGoogle scholar articles
  • Jordi Merino Diabetes Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Jie Hu Division of Women's Health, Department of Medicine at Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Miguel Ruiz-Canela Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain CIBER Fisiopatologıa de la Obesidad y Nutricion, Instituto de Salud Carlos III, Madrid, Spain PubMed articlesGoogle scholar articles
  • Casey Rebholz Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA PubMed articlesGoogle scholar articles
  • Zheng Wang Department of Epidemiology and Population Health, Yeshiva University Albert Einstein College of Medicine, Bronx, New York, USA PubMed articlesGoogle scholar articles
  • Mykhaylo Usyk Departments of Pediatrics, Microbiology and Immunology, and Gynecology and Women's Health, Yeshiva University Albert Einstein College of Medicine, Bronx, New York, USA PubMed articlesGoogle scholar articles
  • Guo-Chong Chen Department of Epidemiology and Population Health, Yeshiva University Albert Einstein College of Medicine, Bronx, New York, USA PubMed articlesGoogle scholar articles
  • Bianca C Porneala Division of General Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Wenshuang Wang Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA Department of Mathematics, University of Houston, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Ngoc Quynh Nguyen Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Elena V Feofanova Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Megan L Grove Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Thomas J Wang Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  • Robert E Gerszten Programs in Metabolism and Medical & Population Genetics, Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Josée Dupuis Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Jordi Salas-Salvadó CIBER Fisiopatologıa de la Obesidad y Nutricion, Instituto de Salud Carlos III, Madrid, Spain Human Nutrition Unit, Faculty of Medicine and Health Sciences, Universidad Rovira i Virgili Departamento de Medicina y Cirurgía, Reus, Spain PubMed articlesGoogle scholar articles
  • Wei Bao Department of Epidemiology, The University of Iowa College of Public Health, Iowa City, Iowa, USA PubMed articlesGoogle scholar articles
  • David L Perkins Institute of Minority Health Research, University of Illinois College of Medicine, Chicago, Illinois, USA PubMed articlesGoogle scholar articles
  • Martha L Daviglus Institute of Minority Health Research, University of Illinois College of Medicine, Chicago, Illinois, USA PubMed articlesGoogle scholar articles
  • Bharat Thyagarajan Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Minneapolis, Minnesota, USA PubMed articlesGoogle scholar articles
  • Jianwen Cai Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • Tao Wang Department of Epidemiology and Population Health, Yeshiva University Albert Einstein College of Medicine, Bronx, New York, USA PubMed articlesGoogle scholar articles
  • JoAnn E Manson Department of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA Division of Preventive Medicine, Department of Medicine at Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Miguel A Martínez-González Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain CIBER Fisiopatologıa de la Obesidad y Nutricion, Instituto de Salud Carlos III, Madrid, Spain PubMed articlesGoogle scholar articles
  • Elizabeth Selvin Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA PubMed articlesGoogle scholar articles
  • Kathryn M Rexrode Division of Women's Health, Department of Medicine at Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Clary B Clish Metabolomics Platform, Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Frank B Hu Channing Division of Network Medicine, Department of Medicine at Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • James B Meigs Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA Division of General Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Rob Knight Department of Pediatrics, School of Medicine; Center for Microbiome Innovation, Department of Computer Science and Engineering, Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA PubMed articlesGoogle scholar articles
  • Robert D Burk Department of Epidemiology and Population Health, Yeshiva University Albert Einstein College of Medicine, Bronx, New York, USA Departments of Pediatrics, Microbiology and Immunology, and Gynecology and Women's Health, Yeshiva University Albert Einstein College of Medicine, Bronx, New York, USA PubMed articlesGoogle scholar articles
  • Eric Boerwinkle Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Robert C Kaplan Department of Epidemiology and Population Health, Yeshiva University Albert Einstein College of Medicine, Bronx, New York, USA Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Qibin Qi, Department of Epidemiology and Population Health, Yeshiva University Albert Einstein College of Medicine, Bronx, New York, USA; qibin.qi{at}einsteinmed.org
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Citation

Qi Q, Li J, Yu B, et al
Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies
Gut 2022;71:1095-1105.

Publication history

  • Received January 7, 2021
  • Accepted June 7, 2021
  • First published June 14, 2021.
Online issue publication 
October 18, 2023

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