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  • STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis

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Original research
STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis

Authors

  • Ruby E Dawson Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, AustraliaDepartment of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Virginie Deswaerte Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, AustraliaDepartment of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Alison C West Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, AustraliaDepartment of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Ke Tang Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, AustraliaDepartment of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Alice J West Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, AustraliaDepartment of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Jesse J Balic Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, AustraliaDepartment of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Linden J Gearing Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, AustraliaDepartment of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Mohamed I Saad Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, AustraliaDepartment of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Liang Yu Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, AustraliaDepartment of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Yonghui Wu Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore PubMed articlesGoogle scholar articles
  • Prithi S Bhathal Department of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Beena Kumar Department of Anatomical Pathology, Monash Health, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Jayati T Chakrabarti Department of Cellular and Molecular Medicine, College of Medicine, University of Arizona, Tucson, Arizona, USA PubMed articlesGoogle scholar articles
  • Yana Zavros Department of Cellular and Molecular Medicine, College of Medicine, University of Arizona, Tucson, Arizona, USA PubMed articlesGoogle scholar articles
  • Hiroko Oshima Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan PubMed articlesGoogle scholar articles
  • Dennis M Klinman Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Masanobu Oshima Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan PubMed articlesGoogle scholar articles
  • Patrick Tan Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, SingaporeGenome Institute of Singapore, SingaporeCancer Science Institute of Singapore, National University of Singapore, Singapore PubMed articlesGoogle scholar articles
  • Brendan J Jenkins Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, AustraliaDepartment of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Brendan J Jenkins, Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia; brendan.jenkins{at}hudson.org.au
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Citation

Dawson RE, Deswaerte V, West AC, et al
STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis
Gut 2022;71:1515-1531.

Publication history

  • Received December 21, 2020
  • Accepted August 27, 2021
  • First published September 6, 2021.
Online issue publication 
July 07, 2022

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© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.