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  • Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours

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Pancreas
Original research
Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours

Authors

  • Hsi-Chien Huang Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • Yun-Chieh Sung Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • Chung-Pin Li Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Division of Clinical Skills Training, Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan PubMed articlesGoogle scholar articles
  • Dehui Wan Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • Po-Han Chao Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • Yu-Ting Tseng Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • Bo-Wen Liao Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • Hui-Teng Cheng Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Biomedical Park Branch, Zhu Bei City, Taiwan Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • Fu-Fei Hsu Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan PubMed articlesGoogle scholar articles
  • Chieh-Cheng Huang Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • Yi-Ting Chen Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • Yu-Hui Liao Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • Hsin Tzu Hsieh Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • Yu-Chuan Shih Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • I-Ju Liu Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan PubMed articlesGoogle scholar articles
  • Han-Chung Wu Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan PubMed articlesGoogle scholar articles
  • Tsai-Te Lu Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • Jane Wang Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  • Yunching Chen Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Yunching Chen, Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan; yunching{at}mx.nthu.edu.tw; Dr Tsai-Te Lu, Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan; ttlu{at}mx.nthu.edu.tw; Dr Jane Wang, Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan; janewang{at}mx.nthu.edu.tw
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Citation

Huang H, Sung Y, Li C, et al
Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours
Gut 2022;71:1843-1855.

Publication history

  • Received May 17, 2021
  • Accepted November 29, 2021
  • First published December 17, 2021.
Online issue publication 
November 15, 2022

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.