Combination therapy of infliximab and thiopurines, but not monotherapy with infliximab or vedolizumab, is associated with attenuated IgA and neutralisation responses to SARS-CoV-2 in inflammatory bowel disease

Judith Wellens; Matthew Edmans; Uri Obolski; Colleen GC McGregor; Peter Simmonds; Marc Turner; Lisa Jarvis; Donal Skelly; Susanna Dunachie; Eleanor Barnes; David W Eyre; Jean-Frederic Colombel; Serre-Yu Wong; Paul Klenerman; James O Lindsay; Jack Satsangi; Craig P Thompson

doi:10.1136/gutjnl-2021-326312

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Combination therapy of infliximab and thiopurines, but not monotherapy with infliximab or vedolizumab, is associated with attenuated IgA and neutralisation responses to SARS-CoV-2 in inflammatory bowel disease

Authors

Judith Wellens Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium Translational Gastroenterology Unit, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Matthew Edmans Translational Gastroenterology Unit, University of Oxford, Oxford, UK Nuffield Department of Medicine, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Uri Obolski School of Public Health, Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel Porter School of Environmental and Earth Sciences, Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv, Israel PubMed articles Google scholar articles
Colleen GC McGregor Translational Gastroenterology Unit, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Peter Simmonds Nuffield Department of Medicine, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Marc Turner National Microbiology Reference Unit, Scottish National Blood Transfusion Service, Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Lisa Jarvis National Microbiology Reference Unit, Scottish National Blood Transfusion Service, Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Donal Skelly Nuffield Department of Medicine, University of Oxford, Oxford, UK Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Susanna Dunachie Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand PubMed articles Google scholar articles
Eleanor Barnes Translational Gastroenterology Unit, University of Oxford, Oxford, UK Nuffield Department of Medicine, University of Oxford, Oxford, UK PubMed articles Google scholar articles
David W Eyre Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK Nuffield Department of Population Health, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Jean-Frederic Colombel Department of Gastroenterology, Mount Sinai School of Medicine, New York, New York, USA PubMed articles Google scholar articles
Serre-Yu Wong The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA PubMed articles Google scholar articles
Paul Klenerman Translational Gastroenterology Unit, University of Oxford, Oxford, UK Nuffield Department of Medicine, University of Oxford, Oxford, UK PubMed articles Google scholar articles
James O Lindsay Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK PubMed articles Google scholar articles
Jack Satsangi Translational Gastroenterology Unit, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Craig P Thompson Warwick Medical School, University of Warwick, Coventry, UK Department of Zoology, University of Oxford, Oxford, UK PubMed articles Google scholar articles

Correspondence to Dr Craig P Thompson, University of Warwick Warwick Medical School, Coventry CV4 7HL, UK; craigpeterthompson{at}gmail.com

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Citation

Wellens J, Edmans M, Obolski U, et al

Gut 2022;71:1919-1922.

Publication history

Received October 13, 2021
Accepted November 6, 2021
First published December 15, 2021.

Online issue publication

November 15, 2022

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© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ. This article is made freely available for personal use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.https://bmj.com/coronavirus/usage

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