Mature tertiary lymphoid structures are key niches of tumour-specific immune responses in pancreatic ductal adenocarcinomas

Gabriela Sarti Kinker; Glauco Akelinghton Freire Vitiello; Ariane Barros Diniz; Mariela Pires Cabral-Piccin; Pedro Henrique Barbosa Pereira; Maria Letícia Rodrigues Carvalho; Wallax Augusto Silva Ferreira; Alexandre Silva Chaves; Amanda Rondinelli; Arianne Fagotti Gusmão; Alexandre Defelicibus; Gabriel Oliveira dos Santos; Warley Abreu Nunes; Laura Carolina López Claro; Talita Magalhães Bernardo; Ricardo Tadashi Nishio; Adhemar Monteiro Pacheco; Ana Carolina Laus; Lidia Maria Rebolho Batista Arantes; Julia Lima Fleck; Victor Hugo Fonseca de Jesus; André de Moricz; Ricardo Weinlich; Felipe José Fernandez Coimbra; Vladmir Cláudio Cordeiro de Lima; Tiago da Silva Medina

doi:10.1136/gutjnl-2022-328697

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Pancreas

Original research

Mature tertiary lymphoid structures are key niches of tumour-specific immune responses in pancreatic ductal adenocarcinomas

Authors

Gabriela Sarti Kinker International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Glauco Akelinghton Freire Vitiello International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Ariane Barros Diniz Hospital Israelita Albert Einstein, São Paulo, Brazil PubMed articles Google scholar articles
Mariela Pires Cabral-Piccin International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Pedro Henrique Barbosa Pereira International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Maria Letícia Rodrigues Carvalho International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Wallax Augusto Silva Ferreira International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil Evandro Chagas Institute, Ananindeua, Brazil PubMed articles Google scholar articles
Alexandre Silva Chaves International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Amanda Rondinelli International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Arianne Fagotti Gusmão International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Alexandre Defelicibus International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Gabriel Oliveira dos Santos Department of Pathology, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Warley Abreu Nunes Department of Pathology, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Laura Carolina López Claro Faculty of Medical Sciences, Santa Casa de Misericórdia do Estado de São Paulo, São Paulo, Brazil PubMed articles Google scholar articles
Talita Magalhães Bernardo Faculty of Medical Sciences, Santa Casa de Misericórdia do Estado de São Paulo, São Paulo, Brazil PubMed articles Google scholar articles
Ricardo Tadashi Nishio Faculty of Medical Sciences, Santa Casa de Misericórdia do Estado de São Paulo, São Paulo, Brazil PubMed articles Google scholar articles
Adhemar Monteiro Pacheco Faculty of Medical Sciences, Santa Casa de Misericórdia do Estado de São Paulo, São Paulo, Brazil PubMed articles Google scholar articles
Ana Carolina Laus Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil PubMed articles Google scholar articles
Lidia Maria Rebolho Batista Arantes Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil PubMed articles Google scholar articles
Julia Lima Fleck Mines Saint-Etienne, Univ Clermont Auvergne, CNRS, UMR 6158 LIMOS, Centre CIS, Saint-Etienne, France PubMed articles Google scholar articles
Victor Hugo Fonseca de Jesus Department of Medical Oncology, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
André de Moricz Faculty of Medical Sciences, Santa Casa de Misericórdia do Estado de São Paulo, São Paulo, Brazil PubMed articles Google scholar articles
Ricardo Weinlich Hospital Israelita Albert Einstein, São Paulo, Brazil PubMed articles Google scholar articles
Felipe José Fernandez Coimbra Department of Surgical Oncology, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Vladmir Cláudio Cordeiro de Lima Department of Medical Oncology, A.C.Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Tiago da Silva Medina International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, São Paulo, Brazil PubMed articles Google scholar articles

Correspondence to Dr Tiago da Silva Medina, International Research Center, A.C.Camargo Cancer Center, São Paulo, 01508-010, Brazil; tiago.medina{at}accamargo.org.br

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Citation

Kinker GS, Vitiello GAF, Diniz AB, et al

Mature tertiary lymphoid structures are key niches of tumour-specific immune responses in pancreatic ductal adenocarcinomas

Gut 2023;72:1927-1941.

Publication history

Received September 15, 2022
Accepted April 27, 2023
First published May 25, 2023.

Online issue publication

October 29, 2023

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