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Not all that is corpus restricted is necessarily autoimmune
  1. Edith Lahner1,
  2. Emanuele Dilaghi2,
  3. Ludovica Dottori1,
  4. Bruno Annibale3
  1. 1 Department of Medical-Surgical Sciences and Translational Medicine, University of Rome La Sapienza, Rome, Lazio, Italy
  2. 2 Medical-Surgical Department of Clinical Sciences and Translational Medicine, Sant’Andrea Hospital, School of Medicine, University Sapienza, University of Rome La Sapienza, Rome, Italy
  3. 3 Clinical Science, University Sapienza Roma, Roma, Italy
  1. Correspondence to Dr Edith Lahner, Department of medical-surgical sciences and translational medicine, University of Rome La Sapienza, Rome, Lazio, Italy; edith.lahner{at}uniroma1.it

https://doi.org/10.1136/gutjnl-2022-328959

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    We read with interest the paper by Rugge et al on the long-term natural history in Helicobacter pylori (Hp)-negative patients with autoimmune gastritis (AIG)1 whose main findings were that (1) corpus-restricted inflammation, pseudopyloric (PPM) rather than intestinal metaplasia (IM), and enterochromaffin like (ECL)-cell hyperplasia and neoplasia were the main histopathological hallmarks associated with AIG; (2) patients with AIG seem not to have an increased gastric cancer (GC)-risk when previous/current Hp infection is thoroughly excluded, but surveillance for type-1 gastric neuroendocrine tumours (t1-gNETs) risk may be performed.

    We fully agree that corpus-restricted inflammation, ECL-cell hyperplasia, t1-gNETs and PPM are findings commonly associated with AIG, although not exclusively present.

    ECL-cell hyperplasia is the consequence of increased gastrin and a result of impaired gastric acid secretion due to oxyntic glands atrophy, over time possibly leading to …

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    Footnotes

    • Contributors All authors drafted the manuscript whose final version was approved by all authors.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.