GWAS meta-analysis of 16 790 patients with Barrett’s oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level

Julia Schröder; Laura Chegwidden; Carlo Maj; Jan Gehlen; Jan Speller; Anne C Böhmer; Oleg Borisov; Timo Hess; Nicole Kreuser; Marino Venerito; Hakan Alakus; Andrea May; Christian Gerges; Thomas Schmidt; Rene Thieme; Dominik Heider; Axel M Hillmer; Julian Reingruber; Orestis Lyros; Arne Dietrich; Albrecht Hoffmeister; Matthias Mehdorn; Florian Lordick; Gertraud Stocker; Michael Hohaus; Daniel Reim; Jennis Kandler; Michaela Müller; Alanna Ebigbo; Claudia Fuchs; Christiane J Bruns; Arnulf H Hölscher; Hauke Lang; Peter P Grimminger; Dani Dakkak; Yogesh Vashist; Sandra May; Siegfried Görg; Andre Franke; David Ellinghaus; Sara Galavotti; Lothar Veits; Josef Weismüller; Jens Dommermuth; Udo Benner; Thomas Rösch; Helmut Messmann; Brigitte Schumacher; Horst Neuhaus; Carsten Schmidt; Thaddäus T Wissinowski; Markus M Nöthen; Wellcome Trust Case Control Consortium 2 (WTCCC2); Esophageal Adenocarcinoma Genetics Consortium (EAGLE); Barrett's and Esophageal Adenocarcinoma Consortium (BEACON); Jing Dong; Jue-Sheng Ong; Matthew F Buas; Aaron P Thrift; Thomas L Vaughan; Ian Tomlinson; David C Whiteman; Rebecca Claire Fitzgerald; Janusz Jankowski; Michael Vieth; Andreas Mayr; Puya Gharahkhani; Stuart MacGregor; Ines Gockel; Claire Palles; Johannes Schumacher

doi:10.1136/gutjnl-2021-326698

Article info

Oesophagus

Original research

GWAS meta-analysis of 16 790 patients with Barrett’s oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level

Authors

Julia Schröder Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany PubMed articles Google scholar articles
Laura Chegwidden Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK PubMed articles Google scholar articles
Carlo Maj Center for Human Genetics, University Hospital of Marburg, Marburg, Germany PubMed articles Google scholar articles
Jan Gehlen Center for Human Genetics, University Hospital of Marburg, Marburg, Germany PubMed articles Google scholar articles
Jan Speller Institute of Medical Biometrics, Informatics and Epidemiology (IMBIE), Medical Faculty, University of Bonn, Bonn, Germany PubMed articles Google scholar articles
Anne C Böhmer Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany PubMed articles Google scholar articles
Oleg Borisov Institute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Bonn, Germany PubMed articles Google scholar articles
Timo Hess Center for Human Genetics, University Hospital of Marburg, Marburg, Germany PubMed articles Google scholar articles
Nicole Kreuser Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Marino Venerito Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany PubMed articles Google scholar articles
Hakan Alakus Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany PubMed articles Google scholar articles
Andrea May Department of Gastroenterology, Oncology and Pneumology, Asklepios Paulinen Clinic Wiesbaden, Wiesbaden, Germany PubMed articles Google scholar articles
Christian Gerges Department of Internal Medicine II, Evangelisches Krankenhaus Dusseldorf, Dusseldorf, Germany PubMed articles Google scholar articles
Thomas Schmidt Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany PubMed articles Google scholar articles
Rene Thieme Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Dominik Heider Department of Mathematics and Computer Science, University of Marburg, Marburg, Germany PubMed articles Google scholar articles
Axel M Hillmer Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Julian Reingruber Center for Human Genetics, University Hospital of Marburg, Marburg, Germany PubMed articles Google scholar articles
Orestis Lyros Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Arne Dietrich Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Albrecht Hoffmeister Department of Gastroenterology, University of Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Matthias Mehdorn Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Florian Lordick University Cancer Center Leipzig (UCCL), Leipzig University Medical Center, Leipzig, Germany PubMed articles Google scholar articles
Gertraud Stocker University Cancer Center Leipzig (UCCL), Leipzig University Medical Center, Leipzig, Germany PubMed articles Google scholar articles
Michael Hohaus Department for General and Visceral Surgery, Städt. Klinikum Dresden Friedrichstadt, Dresden, Germany PubMed articles Google scholar articles
Daniel Reim Department of Surgery, Technical University of Munich, School of Medicine, Klinikum Rechts der Isar, München, Germany PubMed articles Google scholar articles
Jennis Kandler Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Dusseldorf, Medical Faculty of Heinrich Heine University Dusseldorf, Dusseldorf, Germany PubMed articles Google scholar articles
Michaela Müller Department of Gastroenterology, Endocrinology, Metabolism and Infectiology, University Hospital Marburg and Philipps University, Marburg, Germany PubMed articles Google scholar articles
Alanna Ebigbo Department of Gastroenterology, University Hospital Augsburg, Augsburg, Germany PubMed articles Google scholar articles
Claudia Fuchs Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany PubMed articles Google scholar articles
Christiane J Bruns Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany PubMed articles Google scholar articles
Arnulf H Hölscher Department for General, Visceral and Trauma Surgery, Elisabeth-Krankenhaus-Essen GmbH, Essen, Germany PubMed articles Google scholar articles
Hauke Lang Department of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany PubMed articles Google scholar articles
Peter P Grimminger Department of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany PubMed articles Google scholar articles
Dani Dakkak Department of Internal Medicine and Gastroenterology, Elisabeth Hospital Essen, Essen, Germany PubMed articles Google scholar articles
Yogesh Vashist Medias Klinikum, Burghausen, Germany PubMed articles Google scholar articles
Sandra May Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany PubMed articles Google scholar articles
Siegfried Görg Institute of Transfusion Medicine, University Hospital of Schleswig-Holstein, Lübeck/Kiel, Germany PubMed articles Google scholar articles
Andre Franke Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany PubMed articles Google scholar articles
David Ellinghaus Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany PubMed articles Google scholar articles
Sara Galavotti Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK PubMed articles Google scholar articles
Lothar Veits Institute of Pathology, Friedrich-Alexander-Universiät Erlangen-Nürnberg, Klinikum Bayreuth, Bayreuth, Germany PubMed articles Google scholar articles
Josef Weismüller Gastroenterologische Gemeinschaftspraxis, Koblenz, Germany PubMed articles Google scholar articles
Jens Dommermuth Gastroenterologische Gemeinschaftspraxis, Koblenz, Germany PubMed articles Google scholar articles
Udo Benner Gastroenterologische Gemeinschaftspraxis, Koblenz, Germany PubMed articles Google scholar articles
Thomas Rösch Department of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany PubMed articles Google scholar articles
Helmut Messmann Department of Gastroenterology, University Hospital Augsburg, Augsburg, Germany PubMed articles Google scholar articles
Brigitte Schumacher Department of Internal Medicine and Gastroenterology, Elisabeth Hospital Essen, Essen, Germany PubMed articles Google scholar articles
Horst Neuhaus Department of Internal Medicine II, Evangelisches Krankenhaus Dusseldorf, Dusseldorf, Germany PubMed articles Google scholar articles
Carsten Schmidt Medical Clinic II (Gastroenterology, Hepatology, Endocrinology, Diabetology and Infektiology), Klinikum Fulda, University Medicine Marburg—Campus Fulda, Fulda, Germany Medical Faculty, Friedrich Schiller University Jena, Jena, Germany PubMed articles Google scholar articles
Thaddäus T Wissinowski Center for Inner Medicine II, Klinikum Chemnitz gGmbH, Chemnitz, Germany PubMed articles Google scholar articles
Markus M Nöthen Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany PubMed articles Google scholar articles
Wellcome Trust Case Control Consortium 2 (WTCCC2)
Google scholar articles
Esophageal Adenocarcinoma Genetics Consortium (EAGLE)
Google scholar articles
Barrett's and Esophageal Adenocarcinoma Consortium (BEACON)
Google scholar articles
Jing Dong Division of Hematology and Oncology, Department of Medicine, Cancer Center, and Genomic Sciences & Precision Medicine Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA PubMed articles Google scholar articles
Jue-Sheng Ong Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Matthew F Buas Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA PubMed articles Google scholar articles
Aaron P Thrift Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA PubMed articles Google scholar articles
Thomas L Vaughan Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articles Google scholar articles
Ian Tomlinson Edinburgh Cancer Research Centre, IGMM, University of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
David C Whiteman Cancer Control, Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Rebecca Claire Fitzgerald Medical Research Council (MRC) Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Cambridge, Cambridgeshire, UK PubMed articles Google scholar articles
Janusz Jankowski Comprehensive Clinical Trials Unit, University College London, London, UK PubMed articles Google scholar articles
Michael Vieth Institute of Pathology, Friedrich-Alexander-Universiät Erlangen-Nürnberg, Klinikum Bayreuth, Bayreuth, Germany PubMed articles Google scholar articles
Andreas Mayr Institute of Medical Biometrics, Informatics and Epidemiology (IMBIE), Medical Faculty, University of Bonn, Bonn, Germany PubMed articles Google scholar articles
Puya Gharahkhani Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Stuart MacGregor Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Ines Gockel Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Claire Palles Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK PubMed articles Google scholar articles
Johannes Schumacher Center for Human Genetics, University Hospital of Marburg, Marburg, Germany PubMed articles Google scholar articles

Correspondence to Prof Dr Johannes Schumacher, Center for Human Genetics, Universitatsklinikum Giessen und Marburg - Standort Marburg, 35055 Marburg, Germany; johannes.schumacher{at}uni-marburg.de

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Citation

Schröder J, Chegwidden L, Maj C, et al

Gut 2023;72:612-623.

Publication history

Received December 5, 2021
Accepted July 7, 2022
First published July 26, 2022.

Online issue publication

March 07, 2023

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