Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment

Yibo Fan; Yuan Li; Xiaodan Yao; Jiangkang Jin; Ailing Scott; Bovey Liu; Shan Wang; Longfei Huo; Ying Wang; Ruiping Wang; Melissa Pool Pizzi; Lang Ma; Shan Shao; Matheus Sewastjanow-Silva; Rebecca Waters; Deyali Chatterjee; Bin Liu; Namita Shanbhag; Guang Peng; George Adrian Calin; Pawel Karol Mazur; Samir M Hanash; Jo Ishizawa; Yuki Hirata; Osamu Nagano; Zhenning Wang; Linghua Wang; Wa Xian; Frank McKeon; Jaffer A Ajani; Shumei Song

doi:10.1136/gutjnl-2021-326581

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Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment

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Yibo Fan Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Yuan Li Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, PR China PubMed articles Google scholar articles
Xiaodan Yao Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Jiangkang Jin Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Ailing Scott Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Bovey Liu Department of Biology and Biochemistry, University of Houston, Houston, TX, USA PubMed articles Google scholar articles
Shan Wang Department of Biology and Biochemistry, University of Houston, Houston, TX, USA PubMed articles Google scholar articles
Longfei Huo Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Ying Wang Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Ruiping Wang Departments of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Melissa Pool Pizzi Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Lang Ma Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Shan Shao Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Matheus Sewastjanow-Silva Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Rebecca Waters Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Deyali Chatterjee Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Bin Liu Department of Epigenet & Mol Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Namita Shanbhag Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Guang Peng Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
George Adrian Calin Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Pawel Karol Mazur Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Samir M Hanash Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Jo Ishizawa Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Yuki Hirata Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Osamu Nagano Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine Graduate School of Medicine, Tokyo, Japan PubMed articles Google scholar articles
Zhenning Wang Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, PR China PubMed articles Google scholar articles
Linghua Wang Departments of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Wa Xian Department of Biology and Biochemistry, University of Houston, Houston, TX, USA PubMed articles Google scholar articles
Frank McKeon Department of Biology and Biochemistry, University of Houston, Houston, TX, USA PubMed articles Google scholar articles
Jaffer A Ajani Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Shumei Song Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles

Correspondence to Dr Shumei Song, Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; ssong{at}mdanderson.org; Dr Jaffer A Ajani, Departments of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; jajani{at}mdanderson.org; Dr Jaffer A Ajani, Departments of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; jajani{at}mdanderson.org

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Citation

Fan Y, Li Y, Yao X, et al

Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment

Gut 2023;72:624-637.

Publication history

Received November 15, 2021
Accepted August 3, 2022
First published August 24, 2022.

Online issue publication

March 07, 2023

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