NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures

Nai-Yun Hsu; Shikha Nayar; Kyle Gettler; Sayali Talware; Mamta Giri; Isaac Alter; Carmen Argmann; Ksenija Sabic; Tin Htwe Thin; Huai-Bin Mabel Ko; Robert Werner; Christopher Tastad; Thaddeus Stappenbeck; Aline Azabdaftari; Holm H Uhlig; Ling-Shiang Chuang; Judy H Cho

doi:10.1136/gutjnl-2021-326305

Article info

Inflammatory bowel disease

Original research

NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures

Authors

Nai-Yun Hsu Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles
Shikha Nayar The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles
Kyle Gettler Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles
Sayali Talware Division of Gastroenterology, Icahn School of Medicine at Mount Sinai Department of Medicine, New York, New York, USA The Icahn Genomic Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles
Mamta Giri The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles
Isaac Alter The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles
Carmen Argmann Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles
Ksenija Sabic Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles
Tin Htwe Thin Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles
Huai-Bin Mabel Ko Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, USA PubMed articles Google scholar articles
Robert Werner Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles
Christopher Tastad Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles
Thaddeus Stappenbeck Department of Inflammation and Immunity, Lerner Research Institute, Cleveland, Ohio, USA PubMed articles Google scholar articles
Aline Azabdaftari Translational Gastroenterology Unit, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Holm H Uhlig Translational Gastroenterology Unit, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Ling-Shiang Chuang Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles
Judy H Cho Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles

Correspondence to Dr Judy H Cho, Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; judy.cho{at}mssm.edu

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Citation

Hsu N, Nayar S, Gettler K, et al

NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures

Gut 2023;72:654-662.

Publication history

Received October 12, 2021
Accepted August 20, 2022
First published October 3, 2022.

Online issue publication

March 07, 2023

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