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Hepatology
Original research
Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implications

Authors

  • Miguel A Martin-Serrano Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Benjamin Kepecs Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Miguel Torres-Martin Translational Research in Hepatic Oncology, Liver Unit, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain PubMed articlesGoogle scholar articles
  • Emily R Bramel Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Philipp K Haber Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Elliot Merritt Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA The Precision Immunology Institute (PrIISM), Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Alexander Rialdi Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Nesteene Joy Param Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Miho Maeda Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Katherine E Lindblad Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA The Precision Immunology Institute (PrIISM), Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • James K Carter Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Marina Barcena-Varela Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA The Precision Immunology Institute (PrIISM), Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Vincenzo Mazzaferro General Surgery and Liver Transplantation Unit, Department of Oncology and Hemato-Oncology, University of Milan and Istituto Nazionale Tumori, IRCCS Foundation, Milano, Lombardia, Italy PubMed articlesGoogle scholar articles
  • Myron Schwartz Department of Surgery, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Silvia Affo Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, Spain PubMed articlesGoogle scholar articles
  • Robert F Schwabe Department of Medicine, Columbia University, New York, New York, USA PubMed articlesGoogle scholar articles
  • Augusto Villanueva Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Ernesto Guccione Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Scott L Friedman Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Amaia Lujambio Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA The Precision Immunology Institute (PrIISM), Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Anna Tocheva Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA The Precision Immunology Institute (PrIISM), Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Josep M Llovet Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA Translational Research in Hepatic Oncology, Liver Unit, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Swan N Thung Department of Pathology, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Alexander M Tsankov Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Daniela Sia Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Daniela Sia, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA; daniela.sia{at}mssm.edu
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Citation

Martin-Serrano MA, Kepecs B, Torres-Martin M, et al
Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implications
Gut 2023;72:736-748.

Publication history

  • Received November 8, 2021
  • Accepted May 3, 2022
  • First published May 18, 2022.
Online issue publication 
March 07, 2023

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© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.