Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer

Feda H Hamdan; Amro M Abdelrahman; Ana Patricia Kutschat; Xin Wang; Thomas L Ekstrom; Nidhi Jalan-Sakrikar; Catherine Wegner Wippel; Negar Taheri; Liezel Tamon; Waltraut Kopp; Joana Aggrey-Fynn; Aditya V Bhagwate; Roberto Alva-Ruiz; Isaac Lynch; Jennifer Yonkus; Robyn Laura Kosinsky; Jochen Gaedcke; Stephan A Hahn; Jens T Siveke; Rondell Graham; Zeynab Najafova; Elisabeth Hessmann; Mark J Truty; Steven A Johnsen

doi:10.1136/gutjnl-2022-328154

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Pancreas

Original research

Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer

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Feda H Hamdan Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Amro M Abdelrahman Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Ana Patricia Kutschat Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany PubMed articles Google scholar articles
Xin Wang Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany PubMed articles Google scholar articles
Thomas L Ekstrom Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA Robert Bosch Center for Tumor Diseases, Stuttgart, Germany PubMed articles Google scholar articles
Nidhi Jalan-Sakrikar Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Catherine Wegner Wippel Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Negar Taheri Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Liezel Tamon Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany PubMed articles Google scholar articles
Waltraut Kopp Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany Clinical Research Unit 5002 (KFO5002), University Medical Center Göttingen, Göttingen, Germany PubMed articles Google scholar articles
Joana Aggrey-Fynn Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA Robert Bosch Center for Tumor Diseases, Stuttgart, Germany PubMed articles Google scholar articles
Aditya V Bhagwate Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Roberto Alva-Ruiz Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Isaac Lynch Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Jennifer Yonkus Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Robyn Laura Kosinsky Robert Bosch Center for Tumor Diseases, Stuttgart, Germany PubMed articles Google scholar articles
Jochen Gaedcke Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany PubMed articles Google scholar articles
Stephan A Hahn Department of Molecular GI Oncology, Ruhr University Bochum, Bochum, Germany PubMed articles Google scholar articles
Jens T Siveke Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articles Google scholar articles
Rondell Graham Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Zeynab Najafova Robert Bosch Center for Tumor Diseases, Stuttgart, Germany PubMed articles Google scholar articles
Elisabeth Hessmann Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany Clinical Research Unit 5002 (KFO5002), University Medical Center Göttingen, Göttingen, Germany PubMed articles Google scholar articles
Mark J Truty Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Steven A Johnsen Robert Bosch Center for Tumor Diseases, Stuttgart, Germany PubMed articles Google scholar articles

Correspondence to Dr Steven A Johnsen, Robert Bosch Center for Tumor Diseases, Stuttgart, Germany; Steven.Johnsen{at}bosch-health-campus.com; Dr Feda H Hamdan; Hamdan.Feda{at}mayo.edu

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Citation

Hamdan FH, Abdelrahman AM, Kutschat AP, et al

Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer

Gut 2023;72:1174-1185.

Publication history

Received June 28, 2022
Accepted March 1, 2023
First published March 8, 2023.

Online issue publication

May 05, 2023

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