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  • Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis

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Inflammatory bowel disease
Original research
Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis

Authors

  • Haim Leibovitzh Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada Division of Gastroenterology & Hepatology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Sun-Ho Lee Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada Division of Gastroenterology & Hepatology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Juan Antonio Raygoza Garay Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada Division of Gastroenterology & Hepatology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Osvaldo Espin-Garcia Division of Biostatistics, University of Toronto Dalla Lana School of Public Health, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Mingyue Xue Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Anna Neustaeter Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Ashleigh Goethel Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Hien Q Huynh Division of Gastroenterology and Nutrition, Department of Pediatrics, University of Alberta Faculty of Medicine & Dentistry, Edmonton, Alberta, Canada PubMed articlesGoogle scholar articles
  • Anne M Griffiths IBD Center, Department of Paediatrics, Faculty of Medicine, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Dan Turner The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, The Hebrew University of Jerusalem, Shaare Zedek Medical Center, Jerusalem, Israel PubMed articlesGoogle scholar articles
  • Karen L Madsen Department of Medicine, University of Alberta, Edmonton, Alberta, Canada PubMed articlesGoogle scholar articles
  • Paul Moayyedi Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada PubMed articlesGoogle scholar articles
  • A Hillary Steinhart Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada Division of Gastroenterology & Hepatology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Mark S Silverberg Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada Division of Gastroenterology & Hepatology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Colette Deslandres Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Montreal, Saint Justine Hospital, Montreal, Quebec, Canada PubMed articlesGoogle scholar articles
  • Alain Bitton Division of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, Quebec, Canada PubMed articlesGoogle scholar articles
  • David R Mack Division of Gastroenterology, Hepatology & Nutrition, University of Ottawa, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada PubMed articlesGoogle scholar articles
  • Kevan Jacobson Canadian Gastro-Intestinal Epidemiology Consortium, British Columbia Children's Hospital Research Institute, University of British Columbia, British Columbia Children's Hospital, Vancouver, British Columbia, Canada PubMed articlesGoogle scholar articles
  • Maria Cino Department of Medicine, Division of Gastroenterology, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Guy Aumais Department of Medicine, Montreal University, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada PubMed articlesGoogle scholar articles
  • Charles N Bernstein University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre and Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada PubMed articlesGoogle scholar articles
  • Remo Panaccione Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology of Gastroenterology, University of Calgary, Calgary, Alberta, Canada PubMed articlesGoogle scholar articles
  • Batia Weiss Division of Pediatric Gastroenterology, Hepatology and Nutrition, Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, The Edmond and Lily Safra Children's Hospital, Tel Aviv, Israel PubMed articlesGoogle scholar articles
  • Jonas Halfvarson School of Medical Sciences. Department of Gastroenterology, Örebro University, Orebro, Sweden PubMed articlesGoogle scholar articles
  • Wei Xu Division of Biostatistics, University of Toronto Dalla Lana School of Public Health, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Williams Turpin Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada Division of Gastroenterology & Hepatology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Kenneth Croitoru Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada Division of Gastroenterology & Hepatology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Crohn’s and Colitis Canada (CCC) Genetic, Environmental, Microbial (GEM) Project Research Consortium
    Google scholar articles
  1. Correspondence to Dr Kenneth Croitoru, Zane Cohen Centre for Digestive Diseases, Sinai Health System, Toronto, ON M5T 3L9, Canada; kcroitoru{at}mtsinai.on.ca
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Citation

Leibovitzh H, Lee S, Raygoza Garay JA Crohn’s and Colitis Canada (CCC) Genetic, Environmental, Microbial (GEM) Project Research Consortium, et al
Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis
Gut 2023;72:1462-1471.

Publication history

  • Received August 3, 2022
  • Accepted January 25, 2023
  • First published February 14, 2023.
Online issue publication 
August 24, 2023

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© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.