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  • Response to: Correspondence on ‘Definition of age-dependent reference values for the diameter of the common bile duct and pancreatic duct on MRCP: still needed further discussion’ by Wang et al

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Response to: Correspondence on ‘Definition of age-dependent reference values for the diameter of the common bile duct and pancreatic duct on MRCP: still needed further discussion’ by Wang et al
  1. Anke Hannemann1,2,
  2. Julia Mayerle3,
  3. Georg Beyer3
  1. 1 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany
  2. 2 Partner Site Greifswald, German Centre for Cardiovascular Research (DZHK), Greifswald, Germany
  3. 3 Department of Medicine II, Ludwig Maximilian University of Munich, Munchen, Bayern, Germany
  1. Correspondence to Professor Julia Mayerle, Department of Medicine II, Ludwig Maximilian University of Munich, Munchen 81377, Bayern, Germany; julia.mayerle{at}med.uni-muenchen.de

https://doi.org/10.1136/gutjnl-2023-331525

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    We would like to thank Wang et al for their insights and comments on our recently published manuscript ‘Definition of age-dependent reference values for the diameter of the common bile duct and pancreatic duct on MRCP: a population-based, cross-sectional cohort study’.1 2

    We beg to differ: previously, body mass index (BMI) has been proposed as having a moderate influence on duct diameters (r<0.3).3 We assessed the impact of BMI together with sex, age and alanin-aminotransferase (ALAT) on the common bile duct (CBD) and pancreatic duct (PD) diameters in our study population using a multivariable quantile regression model (online supplemental table 21), but observed only very small effects. A 10 kg/m² increase in BMI was associated with a change in CBD or PD diameters of about 0.2 mm. Moreover, group differences in native or secretin-stimulated CBD and PD diameters among normal weight, overweight and obese individuals were not statistically significant (Kruskal-Wallis test p>0.05). We therefore included these participants in our …

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    Footnotes

    • Contributors AH data acquisition, analysis, figures and tables. JM project supervision and study design. GB interpretation of data and manuscript preparation.

    • Funding Supported by the Deutsche Forschungsgemeinschaft (DFG MA 4115/1-2/3, SFB1321: Project-ID 329628492, BE 6395/1-1), the Federal Ministry of Education and Research (BMBF GANI-MED 03IS2061A and BMBF 0314107, 01ZZ9603, 01ZZ0103, 01ZZ0403, 03ZIK012), EFRE-State Ministry of Economics MV (V-630-S150-2012/132/133, ESF/14-BM-A55-0045/16 PePPP and ESF/14-BM-A55-0010/18 EnErGie), Munich Clinician Scientist Program (MCSP) der LMU München, SHIP is part of the Community Medicine Research Network of the University Medicine Greifswald, which is supported by the German Federal State of Mecklenburg—West Pomerania.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.