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Pancreas
Original research
MED12 loss activates endogenous retroelements to sensitise immunotherapy in pancreatic cancer

Authors

  • Yingying Tang State Key Laboratory of Systems Medicine for Cancer, Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China PubMed articlesGoogle scholar articles
  • Shijie Tang Centre of Biomedical Systems and Informatics, ZJU-UoE Institute, Zhejiang University School of Medicine, International Campus, Zhejiang University, Haining, Zhejiang, China PubMed articlesGoogle scholar articles
  • Wenjuan Yang State Key Laboratory of Systems Medicine for Cancer, Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China PubMed articlesGoogle scholar articles
  • Zhengyan Zhang State Key Laboratory of Systems Medicine for Cancer, Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China PubMed articlesGoogle scholar articles
  • Teng Wang Centre of Biomedical Systems and Informatics, ZJU-UoE Institute, Zhejiang University School of Medicine, International Campus, Zhejiang University, Haining, Zhejiang, China PubMed articlesGoogle scholar articles
  • Yuyun Wu Centre of Biomedical Systems and Informatics, ZJU-UoE Institute, Zhejiang University School of Medicine, International Campus, Zhejiang University, Haining, Zhejiang, China PubMed articlesGoogle scholar articles
  • Junyi Xu State Key Laboratory of Systems Medicine for Cancer, Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China PubMed articlesGoogle scholar articles
  • Christian Pilarsky Department of Surgery, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany PubMed articlesGoogle scholar articles
  • Massimiliano Mazzone Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven, Belgium, Leuven, Belgium Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Lei-Wei Wang Department of Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China PubMed articlesGoogle scholar articles
  • Yongwei Sun Department of Biliary and Pancreatic Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China PubMed articlesGoogle scholar articles
  • Ruijun Tian Shenzhen Key Laboratory of Functional Proteomics, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, China PubMed articlesGoogle scholar articles
  • Yujie Tang Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Key Laboratory of Reproductive Medicine, Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China PubMed articlesGoogle scholar articles
  • Yu Wang Department of Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China PubMed articlesGoogle scholar articles
  • Chaochen Wang Centre of Biomedical Systems and Informatics, ZJU-UoE Institute, Zhejiang University School of Medicine, International Campus, Zhejiang University, Haining, Zhejiang, China Department of Breast Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Hangzhou, China Biomedical and Health Translational Research Centre, Zhejiang University, Zhejiang, China PubMed articlesGoogle scholar articles
  • Jing Xue State Key Laboratory of Systems Medicine for Cancer, Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China PubMed articlesGoogle scholar articles
  1. Correspondence to Jing Xue, State Key Laboratory of Systems Medicine for Cancer, Stem Cell Research Center, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; xuejing0904{at}126.com; Dr Chaochen Wang; chaochenwang{at}intl.zju.edu.cn; Dr Yu Wang; wangyu4tc{at}163.com; Dr Yujie Tang; yujietang{at}shsmu.edu.cn
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Citation

Tang Y, Tang S, Yang W, et al
MED12 loss activates endogenous retroelements to sensitise immunotherapy in pancreatic cancer
Gut 2024;73:1999-2011.

Publication history

  • Received March 7, 2024
  • Accepted August 19, 2024
  • First published August 31, 2024.
Online issue publication 
November 11, 2024

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© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.