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Letter
Response to: short-chain fatty acids in patients with severe acute pancreatitis: friend or foe?
  1. Christoph Ammer-Herrmenau,
  2. Albrecht Neesse
  1. Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medicine Goettingen, Goettingen, Germany
  1. Correspondence to Professor Albrecht Neesse, Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medicine Goettingen, Goettingen, Germany; albrecht.neesse{at}med.uni-goettingen.de

https://doi.org/10.1136/gutjnl-2024-332236

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    We write in response to the Letter to the Editor by van den Berg et al 1 commenting on our recent article ‘Gut microbiota predicts severity and reveals novel metabolic signatures in acute pancreatitis’.2 We greatly appreciate the interest in our work and are grateful to clarify some aspects of the study.

    The primary endpoint of our study investigated whether microbial compositions can be employed as early predictors for severity of acute pancreatitis (AP). Patients with revised Atlanta classification III (RAC III) showed highly significant microbial differences compared with RAC I and RAC II. Further analysis revealed a higher abundance of species that are known producers of short-chain fatty acids (SCFA) in severe AP. Van den Berg et al mention the lack of a healthy control cohort, however, it is already known from previous studies that the microbial composition in stool samples of patients with AP is different from healthy controls in the early phase of AP.3

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    Footnotes

    • X @AmmerHerrmenau, @albrechtneesse

    • Contributors CA-H performed the analysis. Both authors wrote the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.