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Poking at probiotic mechanisms and microbial implications in cancer prevention and treatment
  1. Jun Sun1,2,3
  1. 1 University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA
  2. 2 UIC cancer Center, University of Illinois Chicago, Chicago, Illinois, USA
  3. 3 Jesse Brown VA Medical Center, Chicago, Illinois, USA
  1. Correspondence to Dr Jun Sun, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA; junsun7{at}uic.edu

https://doi.org/10.1136/gutjnl-2024-332560

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    In the current microbiome research, we recognise that there is a long journey from identifying a single strain to understanding the altered community, then nailing down the general questions of altered microbiome to the specific role of individual player as a game changer. A recent publication in Gut has shown us one of these journeys to achieve a groundbreaking goal. Su et al 1 have identified a probiotic species Lactococcus lactis reduced in patients with colorectal cancer (CRC) using three independent cohorts. They successfully isolated a new L. lactis strain, HkyuLL 10, from healthy human stools, and verified this strain by whole genome sequencing. HkyuLL 10 treatment is able to suppress tumorigenesis in experimental colon cancer models (Apc min/+ mice and carcinogen-induced azoxymethane (AOM)-dextran sodium sulfate (DSS) mice) by enriching endogenous probiotic species to alleviate microbial dysbiosis. Of note, the protective function of HkyuLL 10 is through α-mannosidase. α-mannosidase made by HkyuLL 10 has demonstrated its beneficial role in suppressing human CRC cells, patient-derived organoids, and CRC in xenograft mice. Interestingly, HkyuLL 10 is able to suppress CRC tumorigenesis in germ-free mice, suggesting that HkyuLL 10 alone is sufficient to confer protective effect in microbiota-depleted mice. Thus, this study has demonstrated that a new strain HkyuLL 10 exhibits protective …

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    Footnotes

    • Contributors JS searched literature and wrote this manuscript.

    • Funding The study was funded by the DOD CDMRP (BC191198), the US Department of Veterans Affairs (VA) Merit Award 1 (I01BX004824-01) and the NIDDK/National Institutes of Health (R01DK134343-01 and R01DK114126 to JS).The study was funded by the DOD CDMRP (BC191198), the US Department of Veterans Affairs (VA) Merit Award 1 (I01BX004824-01) and the NIDDK/National Institutes of Health (R01DK134343-01 and R01DK114126 to JS).

    • Disclaimer The study sponsors play no role in the study design, data collection, analysis and interpretation of data. The contents do not represent the views of the US Department of Veterans Affairs or the US government.

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.

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