Footnotes

• Contributors Conceptualisation: SL, MKM, LD and MG; Software: JR and XP; Investigation, SL and JLH; Data curation, SL and JR; Writing: SL, MKM and LD; Funding acquisition, LD; Resources: AR and RM-L; Supervision, JX, MKM and LD. Authors have approved the final draft of the manuscript.

• Funding This work was funded by the Deutsche Forschungsgemeinschaft (DFG (German Research Foundation)) SFB1371/1-395357507 (project P09) to LD and MG and DFG project DE 2360/1-1 (Emmy Noether Program, project number 273124240) to LD, EU ERC StG-GA No. 803077 to LD.

• Competing interests None declared.

• Provenance and peer review Not commissioned; internally peer reviewed.

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