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Author reply to: Increased Incidence of GERD in GLP-1 treated patients – fact or artefact?
  1. Benjamin Douglas Liu1,
  2. Gengqing Song2
  1. 1 Internal Medicine, MetroHealth Medical Center, Cleveland, Ohio, USA
  2. 2 Department of Gastroenterology and Hepatology, Case Western Reserve University, Cleveland, Ohio, USA
  1. Correspondence to Dr Gengqing Song, Department of Gastroenterology and Hepatology, Case Western Reserve University, Cleveland, Ohio, USA; songgavin2010{at}gmail.com

https://doi.org/10.1136/gutjnl-2023-331411

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    We express our gratitude to Quast and Meier1 for their meticulous assessment of our recent publication. Their feedback offers a unique opportunity to enhance our explanations.

    Regarding the influence of diabetes duration on gastroparesis prevalence, we agree on its significance. However, our methodology used propensity matching based on the presence of diabetes with neurological complications, as shown in the supplemental tables 1 and 2 in the original article,2 as well as the general diagnosis of type 2 diabetes. This approach serves as a proxy for diabetes severity and related complications, offering a more nuanced control than merely accounting for diabetes duration.

    While undiagnosed gastroparesis prior to the index date is a potential concern, our comparison of diabetes medications ensured a similar patient distribution. Additionally, by matching based on the most recent A1c levels prior to second-line diabetes medication prescription, we ensured that both cohorts were aligned in terms of their diabetes severity and thus, the likelihood of undiagnosed gastroparesis.

    In response to new PPI usage and GLP-1 …

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    Footnotes

    • Contributors BDL: conceptualisation, drafting, editing manuscript. GS: conceptualisation, project supervision, writing, editing manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.