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  • IDDF2024-ABS-0188 Gamma-glutamyl transferase to aspartate aminotransferase ratio (GSR) predicts prognoses in patients with colorectal cancer with liver metastasis after microwave ablation

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Clinical Gastroenterology
IDDF2024-ABS-0188 Gamma-glutamyl transferase to aspartate aminotransferase ratio (GSR) predicts prognoses in patients with colorectal cancer with liver metastasis after microwave ablation
  1. Mingzhe Huang1,
  2. Zhiliang Chen2,
  3. Si Qin3,
  4. Jiaming Zhou1,
  5. Yan Huang4,
  6. Shaoyong Peng1,
  7. Pinzhu Huang1,
  8. Maram Alenzi5,
  9. Jun Huang1,
  10. Jing Lin3,
  11. Zhiyong Chen6,
  12. Meijin Huang1
  1. 1Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, China
  2. 2Department of General Surgery, Affiliated Dongguan People’s Hospital, Southern Medical University (Dongguan People’s Hospital), China
  3. 3Department of Ultrasound, The Sixth Affiliated Hospital, Sun Yat-sen University, China
  4. 4Department of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University, China
  5. 5Gastroenterology Department, Beth Israel Deaconess Center, Harvard Medical School, China
  6. 6The Fourth Department of General Surgery, Zhongshan People’s Hospital, China

Abstract

Background Microwave ablation (MWA) is widely used to eliminate colorectal liver metastases (CRLM). However, the risk of tumor recurrence is difficult to predict due to the lack of reliable clinical and biological markers. Elevation of gamma-glutamyl transferase (GGT) and aspartate transaminase (AST) provides signals for liver inflammation and cancer progression. The present study evaluated the association between pre-ablation GGT to AST ratio index (GSR) and hepatic recurrence in patients with CRLM after MWA.

Methods A retrospectively analyzed 192 CRLM patients who underwent MWA from January 2013 to January 2017 (IDDF2024-ABS-0188 Figure 1). Pre-ablation GSR was classified into high (≤ 2.34) or low (>2.34) using the upper quartile value. The prognostic value of GSR and other risk factors for liver progression-free survival (LPFS) and cancer-specific survival (CSS) were evaluated by univariate and multivariate analyses.

Results High GSR was significantly associated with males (P = 0.041), the presence of cholelithiasis (P = 0.012), but not pre-ablation chemotherapy (P = 0.355), which caused significantly increased levels of GGT (P = 0.015) and AST (P = 0.008). GSR showed a significant association with LPFS and CSS through univariate analysis (P = 0.002 and 0.006, IDDF2024-ABS-0188 Figure 2) and multivariate analysis (P = 0.043 and 0.037, IDDF2024-ABS-0188 Figure 3, IDDF2024-ABS-0188 Figure 4). The subgroup analysis demonstrated no interaction between GSR and all variables except for distribution in the sub-analysis of LPFS (IDDF2024-ABS-0188 Figure 5, IDDF2024-ABS-0188 Figure 6).

Abstract IDDF2024-ABS-0188 Figure 1
Abstract IDDF2024-ABS-0188 Figure 1
Abstract IDDF2024-ABS-0188 Figure 2
Abstract IDDF2024-ABS-0188 Figure 2
Abstract IDDF2024-ABS-0188 Figure 3
Abstract IDDF2024-ABS-0188 Figure 3
Abstract IDDF2024-ABS-0188 Figure 4
Abstract IDDF2024-ABS-0188 Figure 4
Abstract IDDF2024-ABS-0188 Figure 5
Abstract IDDF2024-ABS-0188 Figure 5
Abstract IDDF2024-ABS-0188 Figure 6
Abstract IDDF2024-ABS-0188 Figure 6

Conclusions Measuring GSR in CRLM patients before MWA was a convenient and economical way to predict prognosis.

https://doi.org/10.1136/gutjnl-2024-IDDF.272

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