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Abstract
Background In individuals with acute pancreatitis (AP), abdominal effusion is a significant predictor of severity and prognosis. It is unclear whether the color and other characteristics of ascites are related to the prognosis of AP patients. Compare the differences in color depth and turbidity of ascites in the early stages of AP patients, and investigate whether the characteristics of ascites are related to the clinical prognosis of acute pancreatitis.
Methods 667 AP patients with ascites were studied (IDDF2024-ABS-0342 Figure 1. Research flowchart). Ascites were characterized by color depth and turbidity as yellow clear (n=54), yellow turbidity (n=293), red bloody (n=210), and brown (n=110). The trend Chi-square test was used to compare the incidence of organ failure infected pancreatic necrosis (IPN), and mortality among the four ascites patient groups. The ROC curve was used to analyze the role of cell count, amylase, protein, and lactate dehydrogenase (LDH) in ascites for predicting abdominal compartment syndrome (ACS) and intraabdominal hemorrhage.
Results AP patients with ascites showed higher clinical scores (SIRS, BISAP, APACHEII, and CTSI) and higher incidence of complications and mortality (all P <0.05) compared to those without ascites. In the four groups, ascites color altered from light to dark and turbidity from clear to murky; correspondingly, the incidence of organ failure, pancreatic necrosis, IPN and mortality were linearly related (P<0.05) (IDDF2024-ABS-0342 Figure 2. Clinical outcomes of AP patients with different characteristics of ascites). ROC curve analysis revealed that LDH in ascites accurately predicted intraabdominal hemorrhage and ACS with an area under the curve of 0.77 and 0.79 (IDDF2024-ABS-0342 Figure 3. The predictive accuracy of the components of ascites for ACS, IDDF2024-ABS-0342 Figure 4. The predictive accuracy of the components of ascites for intraabdominal hemorrhage).
Research flowchart.
Clinical outcomes of AP patients with different characteristics of ascites.
The predictive accuracy of the components of ascites for ACS.
The predictive accuracy of the components of ascites for intraabdominal hemorrhage.
Conclusions In the early stage of AP, patients with ascites are associated with a higher incidence of organ failure, IPN, and mortality than those without ascites, and are linearly correlated with color depth and turbidity. LDH in ascites can accurately predict ACS and intraintraabdominal hemorrhage in AP patients.