You are here

  • Home
  • Archive
  • Volume 73, Issue Suppl 2
  • IDDF2024-ABS-0423 Global, national and regional burden of digestive congenital anomalies and its trend in 204 countries and territories from 1990-2021: a benchmarking global analysis

Article Text

Article menu
Download PDFPDF
Clinical Gastroenterology
IDDF2024-ABS-0423 Global, national and regional burden of digestive congenital anomalies and its trend in 204 countries and territories from 1990-2021: a benchmarking global analysis
  1. George Mathew Mukalil1,
  2. Vani Sojitra2,
  3. Ishita Hirpara3,
  4. Khalid Faris4,
  5. Pavan Bolla5,
  6. Mohammed AS Aramin6,
  7. Urvashi Rathod7,
  8. Praveena Suppala8,
  9. Venkata Ramana Katikala5,
  10. Hardik Dineshbhai Desai9
  1. 1Department of Internal Medicine, Central Michigan University, Saginaw, Michigan, United States
  2. 2Pandit Deendayal Upadhyay Medical College, Rajkot, India
  3. 3G.M.E.R.S Medical College, Junagadh, Gujarat, India
  4. 4Studied in Al-Quds university, at Al-Zaytoona for science and technology, Gaza Strip
  5. 5Konaseema Institute of Medical Sciences & Research Foundation, Amalapuram, Andhra Pradesh, India
  6. 6Alquds University, Jerusalem, West Bank, Gaza Strip
  7. 7Narendra Medical College, Maninagar, Ahmedabad, Gujarat, India
  8. 8SVS Medical College, Yenugonda, Mahbubnagar, Telangana, India
  9. 9Gujarat Adani Institute of Medical Sciences, Affiliated to K.S.K.V University, Bhuj, Gujarat, India

Abstract

Background Digestive Congenital Anomalies (DCA) rank as the fourth leading cause of death and disability among all congenital anomalies. This pioneering study examines the burden of DCA over the last three decades, including the initial two years of the COVID-19 pandemic, which significantly challenged the management of non-COVID cases.

Methods Utilizing the Global Burden of Disease (GBD) framework, we estimated the incidence, prevalence, Disability-Adjusted Life Years (DALYs), and Years Lived with Disability (YLDs) by age, sex, year, and location across 204 countries and territories from 1990-2021. Non-fatal health outcomes were analyzed using DISMOD MR 2.1, a meta-regression tool, while fatal outcomes were assessed with the Cause of Death Ensemble model (CODEm).

Results The total number of DCA cases rose from 2.9 million (95% Uncertainty Interval [UI]: 2.3-3.5) in 1990 to 3.2 million (UI: 2.6-3.8) in 2021. There was an 11% increase (UI: 3%-21%) in YLDs from 1990 to 2021 (IDDF2024-ABS-0423 Figure 1). Regionally, Oceania observed the highest TPC increase in incidence counts by 131% (UI: 102%-163%), and the highest increase in deaths by 83%, followed by Western Sub-Saharan Africa at 65%, while other regions saw decreases (IDDF2024-ABS-0423 Figure 2, IDDF2024-ABS-0423 Figure 3, IDDF2024-ABS-0423 Figure 4). Countries with a low Socio-Demographic Index (SDI) recorded the highest rise in incidence counts by 44%, followed by deaths at 17% and YLDs at 74%. Males exhibited a generally higher burden than females, with YLDs increasing by 14% in males versus 18% in females.

Abstract IDDF2024-ABS-0423 Figure 1
Abstract IDDF2024-ABS-0423 Figure 1
Abstract IDDF2024-ABS-0423 Figure 2
Abstract IDDF2024-ABS-0423 Figure 2
Abstract IDDF2024-ABS-0423 Figure 3
Abstract IDDF2024-ABS-0423 Figure 3
Abstract IDDF2024-ABS-0423 Figure 4
Abstract IDDF2024-ABS-0423 Figure 4

Conclusions In 2021, DCAs accounted for 9.13% of all deaths from congenital defects. Effective management of DCA from a public health perspective should focus on enhancing prenatal care, promoting genetic counseling, and improving neonatal services. From a clinical perspective, early diagnosis and personalized treatment plans are crucial. Patients and their families would benefit from greater access to support services and information about managing DCA to improve their quality of life.

https://doi.org/10.1136/gutjnl-2024-IDDF.336

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.