Objetive: Colonoscopy is one of the methods of choice for screening relatives of patients with colorectal cancer. To evaluate the rate of adherence to colonoscopy in first-degree relatives of patients with colorectal cancer and describe the lesions found.
Design: We conducted a prospective, cross- sectional, multicenter, nationwide study. The study population was composed of first-degree relatives of patients with colorectal cancer selected randomly from the EPICOLON study. Seventy-four index patients were included. These had 342 living first-degree relatives (parents, siblings, and children), of whom we interviewed 281.
Results: The adherence rate was 38% (107/281). Adherence was greater in families with a higher degree of familial aggregation for colorectal cancer (88,9% for Amsterdam vs. 33,3% for Bethesda and sporadic cancer) (P<0.05), an index patient aged under 65 years (60 percent for patients <65 years vs. 32.9 percent for patients ≥65 years; P<0.05), and an index patient who was female (46.2 percent for women vs. 31 percent for men; P=0.28). Adherence was also greater in relatives under 65 years (54 percent in patients <65 years vs. 18 percent in patients ≥65 years; P=0.05), in female relatives (49 percent in female relatives vs. 27.3 percent in male relatives) and in siblings and children (40% in sibling and children vs. 13% in parents; P<0.05). Lesions were found in 26% (28/107) of the study population. Nine (8.4 percent) individuals had a total of 18 advanced lesions.
Conclusions: These results indicate that adherence to colonoscopy in our population of first- degree relatives was low, and was more frequently associated with a higher degree of familial aggregation, a relative age of under 65 years, a sibling or offspring relationship, and female sex.
- colorectal cancer
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