There has been recent progress in the isolation and characterization of stem/progenitor cells that may differentiate towards the hepatic lineage. This has raised expectations that therapy of genetic or acquired liver disease might be possible by transplanting stem/progenitor cells or their liver committed progeny. However, it is currently impossible to determine from the many documented studies which of the stem/progenitor cell populations are the best for therapy of a given disease. This is largely because of the great variability in methods used to characterize cells and their differentiation ability, variability in transplantation models and inconsistent methods to determine the effect of cell grafting in vivo. This manuscript represents a first proposal, created by a group of investigators ranging from basic biologists to clinical Hepatologists. It aims to define standardized methods to assess stem/progenitor cells or their hepatic lineage-committed progeny that could be used for cell therapy in liver disease. Furthermore standardisation is suggested for both preclinical animal models to evaluate the ability of such cells to functionally repopulate the liver, as well as for the ongoing clinical trials using mature hepatocytes. Only when these measures have been put in place the promise of stem/progenitor derived hepatocyte based therapies will become reality.
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