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Serrated polyposis syndrome (SPS) is a recently recognised high risk condition for colorectal cancer (CRC) characterised by the presence of large and/or multiple serrated polyps in the colon.1 ,2 The prevalence of SPS has been previously estimated out of CRC endoscopy-based screening programmes on average risk individuals; in this setting, the prevalence ranged from 0.033% (1/3000 sigmoidoscopies)3 to 0.055% (1/1818 colonoscopies).4 However, Biswas et al5 recently published a higher prevalence based on a guaiac faecal occult blood testing (gFOBT) CRC screening programme in the UK (NHS Bowel Cancer Screening Programme). In this programme, between April 2010 and January 2012, 5/755 (0.66%) patients attended for index screening colonoscopy after a positive gFOBT met the WHO criteria for SPS, which represented a 20-fold increase …
Contributors FB, AC, MA: study concept and design; FB, LM, MP, SC, XB, TO, AS, JG, FM: acquisition of data; FB, LM: analysis and interpretation of data; FB, LM: drafting of the manuscript; MA, AC: critical revision of the manuscript for important intellectual content; FB, LM: statistical analysis.
Competing interests None.
Patient consent Obtained.
Ethics approval IRB of each participating institution.
Provenance and peer review Not commissioned; internally peer reviewed.