Article Text

other Versions

Download PDFPDF
Letter
Paradoxical responses of plasma glucagon and bile acid levels after duodenal nutrient exclusion
  1. Po-Chun Chen1,
  2. Akio Inui2,
  3. Chih-Yen Chen3,4
  1. 1Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
  2. 2Department of Psychosomatic Internal Medicine, Kagoshima University Graduate, School of Medical and Dental Sciences, Kagoshima, Japan
  3. 3Division of Gastroenterology, Department of Medicine Taipei Veterans General Hospital, Taipei, Taiwan
  4. 4Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
  1. Correspondence to Dr Chih-Yen Chen, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, Republic of China; chency{at}vghtpe.gov.tw

Statistics from Altmetric.com

Dear Sir,

We read with interest the article by Habegger et al1 who demonstrated that duodenal nutrient exclusion using duodenal endoluminal sleeve (DES) improves metabolic syndrome and stimulates intestinal villus hyperplasia, especially the bypassed duodenum, in a rodent model of type 2 diabetes mellitus. There were three intriguing results. First, with regard to DES improving glucose homeostasis, the area under curve analysis showed that both sham-operated and the DES group had statistically significant improvements in glucose homeostasis. Nevertheless, since the pair-fed group had received the same sham operation, it is interesting that the sham-operated group rather than the pair-fed group showed …

View Full Text

Footnotes

  • Contributors All authors contributed equally in this manuscript.

  • Funding The project was funded in part by an intramural grant from Taipei Veterans General Hospital, Taipei, Taiwan (V103C-056).

  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Small bowel
    Kirk M Habegger Omar Al-Massadi Kristy M Heppner Andriy Myronovych Jenna Holland Jose Berger Chun-Xia Yi Yuanging Gao Maarit Lehti Nickki Ottaway Sarah Amburgy Christine Raver Timo D Müller Paul T Pfluger Rohit Kohli Diego Perez-Tilve Randy J Seeley Matthias H Tschöp