A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling

Bo Kong; Weiwei Wu; Tao Cheng; Anna Melissa Schlitter; Chengjia Qian; Philipp Bruns; Ziying Jian; Carsten Jäger; Ivonne Regel; Susanne Raulefs; Nora Behler; Martin Irmler; Johannes Beckers; Helmut Friess; Mert Erkan; Jens T Siveke; Andrea Tannapfel; Stephan A Hahn; Fabian J Theis; Irene Esposito; Jörg Kleeff; Christoph W Michalski

doi:10.1136/gutjnl-2014-307616

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Pancreas

Original article

A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling

Authors

Bo Kong Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Weiwei Wu Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Tao Cheng Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Anna Melissa Schlitter Institute of Pathology, TUM, Munich, Germany PubMed articles Google scholar articles
Chengjia Qian Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Philipp Bruns Department of Surgery, Technische Universität München (TUM), Munich, Germany Institute of Computational Biology, Helmholtz-Zentrum München, Munich, Germany PubMed articles Google scholar articles
Ziying Jian Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Carsten Jäger Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Ivonne Regel Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Susanne Raulefs Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Nora Behler Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Martin Irmler Institute of Experimental Genetics (IEG), Helmholtz-Zentrum München, Munich, Germany PubMed articles Google scholar articles
Johannes Beckers Institute of Experimental Genetics (IEG), Helmholtz-Zentrum München, Munich, Germany Technische Universität München, Chair of Experimental Genetics, Freising, Germany Deutsches Zentrum für Diabetesforschung (DZD), Neuherberg, Germany PubMed articles Google scholar articles
Helmut Friess Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Mert Erkan Department of Surgery, Koc University School of Medicine, Istanbul, Turkey PubMed articles Google scholar articles
Jens T Siveke Department of Gastroenterology, TUM, Munich, Germany PubMed articles Google scholar articles
Andrea Tannapfel Institute of Pathology, Ruhr-University Bochum, Bochum, Germany PubMed articles Google scholar articles
Stephan A Hahn Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany PubMed articles Google scholar articles
Fabian J Theis Institute of Computational Biology, Helmholtz-Zentrum München, Munich, Germany PubMed articles Google scholar articles
Irene Esposito Institute of Pathology, TUM, Munich, Germany PubMed articles Google scholar articles
Jörg Kleeff Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Christoph W Michalski Department of Surgery, University of Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles

Correspondence to Dr Christoph W Michalski, Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany; cwmichalski{at}gmail.com

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Citation

Kong B, Wu W, Cheng T, et al

A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling

Gut 2016;65:647-657.

Publication history

Received May 7, 2014
Revised December 7, 2014
Accepted December 22, 2014
First published January 19, 2015.

Online issue publication

February 28, 2018

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