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  • Common variants at PRSS1–PRSS2 and CLDN2–MORC4 loci associate with chronic pancreatitis in Japan

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Common variants at PRSS1–PRSS2 and CLDN2–MORC4 loci associate with chronic pancreatitis in Japan
  1. Atsushi Masamune,
  2. Eriko Nakano,
  3. Shin Hamada,
  4. Yoichi Kakuta,
  5. Kiyoshi Kume,
  6. Tooru Shimosegawa
  1. Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
  1. Correspondence to Dr Atsushi Masamune, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574 Japan; amasamune{at}med.tohoku.ac.jp

https://doi.org/10.1136/gutjnl-2015-309802

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    To the Editor,

    We read with great interest the article by Derikx et al1 reporting a replication study of the association between common variants at the PRSS1–PRSS2 and CLDN2–MORC4 loci and chronic pancreatitis (CP). In agreement with the results originally reported by Whitcomb et al,2 they showed that the rs10273639 T allele at the PRSS1–PRSS2 locus protected against CP, whereas the rs7057398 C allele in RIPPLY1 and rs12688220 T allele in MORC4 at the CLDN2–MORC4 locus increased disease susceptibility.1 It has been recognised that geographical differences exist in the genetics of pancreatitis.3 Because the previous studies1 ,2 employed subjects of European ancestry only, we aimed to refine the association in Japanese patients with CP.

    The three variants were genotyped by direct sequencing in 272 patients (men, n=245) with alcoholic CP (ACP), 197 patients …

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    Footnotes

    • Contributors AM and TS designed the project. AM, EN, SH, YK and KK performed the experiments. AM wrote the manuscript.

    • Funding This work was supported in part by the HIROMI Medical Research Foundation (to AM), by the Mother and Child Health Foundation (to AM), by the Smoking Research Foundation (to AM), by the Pancreas Research Foundation of Japan (to EN) and by the Ministry of Health, Labour and Welfare of Japan.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Ethics approval The Ethics Committee of Tohoku University Graduate School of Medicine (article#: 2014-1-246 and 2014-1-681).

    • Provenance and peer review Not commissioned; internally peer reviewed.