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Gut microbiota
Original article
Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism

Authors

  • Thibaut Duparc WELBIO- Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Hubert Plovier WELBIO- Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Vannina G Marrachelli Fundación de Investigación del Hospital Clínico Universitario de Valencia, INCLIVA, Valencia, Spain PubMed articlesGoogle scholar articles
  • Matthias Van Hul WELBIO- Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Ahmed Essaghir de Duve Institute, Université catholique de Louvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Marcus Ståhlman Wallenberg Laboratory/Sahlgrenska Center for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, Gothenburg, Sweden Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden PubMed articlesGoogle scholar articles
  • Sébastien Matamoros WELBIO- Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Lucie Geurts WELBIO- Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Mercedes M Pardo-Tendero Fundación de Investigación del Hospital Clínico Universitario de Valencia, INCLIVA, Valencia, Spain PubMed articlesGoogle scholar articles
  • Céline Druart WELBIO- Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Nathalie M Delzenne Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Jean-Baptiste Demoulin de Duve Institute, Université catholique de Louvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Schalk W van der Merwe Laboratory of Hepatology, University of Leuven (KUL), Belgium Department of Gastroenterology and Hepatology, Division of Liver and Biliopancreatic Disorders, KUL, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Jos van Pelt Laboratory of Hepatology, University of Leuven (KUL), Belgium PubMed articlesGoogle scholar articles
  • Fredrik Bäckhed Wallenberg Laboratory/Sahlgrenska Center for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, Gothenburg, Sweden Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark PubMed articlesGoogle scholar articles
  • Daniel Monleon Fundación de Investigación del Hospital Clínico Universitario de Valencia, INCLIVA, Valencia, Spain PubMed articlesGoogle scholar articles
  • Amandine Everard WELBIO- Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Patrice D Cani WELBIO- Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Patrice D Cani, Université catholique de Louvain, WELBIO, LDRI, Metabolism and Nutrition research group, Av. E. Mounier, 73 box B1.73.11, Brussels B-1200, Belgium; patrice.cani{at}uclouvain.be
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Citation

Duparc T, Plovier H, Marrachelli VG, et al
Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism
Gut 2017;66:620-632.

Publication history

  • Received October 14, 2015
  • Revised March 1, 2016
  • Accepted March 3, 2016
  • First published May 5, 2016.
Online issue publication 
October 26, 2017

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/