Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy

Bo Kong; Philipp Bruns; Nora A Behler; Ligong Chang; Anna Melissa Schlitter; Jing Cao; Andreas Gewies; Jürgen Ruland; Sina Fritzsche; Nataliya Valkovskaya; Ziying Jian; Ivonne Regel; Susanne Raulefs; Martin Irmler; Johannes Beckers; Helmut Friess; Mert Erkan; Nikola S Mueller; Susanne Roth; Thilo Hackert; Irene Esposito; Fabian J Theis; Jörg Kleeff; Christoph W Michalski

doi:10.1136/gutjnl-2015-310913

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Pancreas

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Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy

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Bo Kong Department of Surgery, Technische Universität München (TUM), Munich, Germany Department of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, China PubMed articles Google scholar articles
Philipp Bruns Department of Surgery, Technische Universität München (TUM), Munich, Germany Institute of Computational Biology, Helmholtz-Zentrum München GmbH, Neuherberg, Germany PubMed articles Google scholar articles
Nora A Behler Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Ligong Chang Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Anna Melissa Schlitter Institute of Pathology, TUM, Munich, Germany PubMed articles Google scholar articles
Jing Cao Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Andreas Gewies Institute für Klinische Chemie und Pathobiochemie, TUM, Munich, Germany Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, Neuherberg, Germany German Cancer Consortium (DKTK) at the partner site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articles Google scholar articles
Jürgen Ruland Institute für Klinische Chemie und Pathobiochemie, TUM, Munich, Germany German Cancer Consortium (DKTK) at the partner site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany PubMed articles Google scholar articles
Sina Fritzsche Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Nataliya Valkovskaya Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Ziying Jian Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Ivonne Regel Institute of Pathology, Heinrich-Heine University, Duesseldorf, Germany PubMed articles Google scholar articles
Susanne Raulefs Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Martin Irmler Institute of Experimental Genetics, Helmholtz Zentrum München GmbH, Neuherberg, Germany PubMed articles Google scholar articles
Johannes Beckers Institute of Experimental Genetics, Helmholtz Zentrum München GmbH, Neuherberg, Germany Chair of Experimental Genetics, Technische Universität München, Freising, Germany Deutsches Zentrum für Diabetesforschung, Neuherberg, Germany PubMed articles Google scholar articles
Helmut Friess Department of Surgery, Technische Universität München (TUM), Munich, Germany PubMed articles Google scholar articles
Mert Erkan Department of Surgery, Koc University, Istanbul, Turkey PubMed articles Google scholar articles
Nikola S Mueller Institute of Computational Biology, Helmholtz-Zentrum München GmbH, Neuherberg, Germany PubMed articles Google scholar articles
Susanne Roth Department of Surgery, University of Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles
Thilo Hackert Department of Surgery, University of Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles
Irene Esposito Institute of Pathology, Heinrich-Heine University, Duesseldorf, Germany PubMed articles Google scholar articles
Fabian J Theis Institute of Computational Biology, Helmholtz-Zentrum München GmbH, Neuherberg, Germany Department of Mathematics, TUM, Munich, Germany PubMed articles Google scholar articles
Jörg Kleeff Department of Surgery, Technische Universität München (TUM), Munich, Germany NIHR Pancreas Biomedical Research Unit, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK PubMed articles Google scholar articles
Christoph W Michalski Department of Surgery, University of Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles

Correspondence to Dr Christoph W Michalski, Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany; cwmichalski{at}gmail.com

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Citation

Kong B, Bruns P, Behler NA, et al

Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy

Gut 2018;67:146-156.

Publication history

Received October 21, 2015
Revised August 15, 2016
Accepted August 23, 2016
First published September 19, 2016.

Online issue publication

March 26, 2018

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