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Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report
  1. P Malfertheiner1,
  2. F Megraud2,
  3. C A O'Morain3,
  4. J P Gisbert4,5,
  5. E J Kuipers6,
  6. A T Axon7,
  7. F Bazzoli8,
  8. A Gasbarrini9,
  9. J Atherton10,
  10. D Y Graham11,
  11. R Hunt12,13,
  12. P Moayyedi14,
  13. T Rokkas15,
  14. M Rugge16,
  15. M Selgrad17,
  16. S Suerbaum18,
  17. K Sugano19,
  18. E M El-Omar20
  19. on behalf of the European Helicobacter and Microbiota Study Group and Consensus panel
  1. 1Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
  2. 2Laboratoire de Bactériologie, Inserm U853, Université de Bordeaux, Bordeaux, France
  3. 3Faculty of Health Sciences, Trinity College, Dublin, Ireland
  4. 4Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IP), Madrid, Spain
  5. 5Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain
  6. 6Erasmus University Medical Center, Rotterdam, The Netherlands
  7. 7General Infirmary Leeds, UK
  8. 8Internal Medicine and Gastroenterology, University of Bologna Italy, Bologna, Italy
  9. 9Gastroenterology, and Liver Unit, Internal Medicine, Roma, Italy
  10. 10Nottingham, UK
  11. 11Department of Medicine (111D), Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
  12. 12Department of Medicine, McMaster University, Hamilton, Canada
  13. 13Hillcroft, Beaconsfield, Buckinghamshire, UK
  14. 14Department of Gastroenterology, McMaster University, Hamilton, Canada
  15. 15Department of Gastroenterology, Henry Dunant Hospital, Athens, Greece
  16. 16Department of Diagnostic Sciences, University of Padova, Padova, Italy
  17. 17Regensburg, Germany
  18. 18Medizinische Hochschule Hannover, Institut für Medizinische Mikrobiologie, Hannover, Germany
  19. 19Department of Medicine, Jichi Medical School, Tochigi, Japan
  20. 20St George and Sutherland Clinical School, University of New South Wales, Sydney, Australia
  1. Correspondence to Professor P Malfertheiner, University of Magdeburg, Department of Gastroenterology, Hepatology and Infectious Diseases, Leipziger Str. 44, Magdeburg 39120, Germany; peter.malfertheiner{at}


Important progress has been made in the management of Helicobacter pylori infection and in this fifth edition of the Maastricht Consensus Report, key aspects related to the clinical role of H. pylori were re-evaluated in 2015. In the Maastricht V/Florence Consensus Conference, 43 experts from 24 countries examined new data related to H. pylori in five subdivided workshops: (1) Indications/Associations, (2) Diagnosis, (3) Treatment, (4) Prevention/Public Health, (5) H. pylori and the Gastric Microbiota. The results of the individual workshops were presented to a final consensus voting that included all participants. Recommendations are provided on the basis of the best available evidence and relevance to the management of H. pylori infection in the various clinical scenarios.


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  • Contributors L. Agreus (Sweden), L.P. Andersen (Denmark), J. Atherton (UK), A. Axon (UK), F. Bazzoli (Italy), L. Coelho (Brazil), J.C. Delchier (France), F. Di Mario (Italy), M. Dinis-Ribeiro (Portugal), E. El-Omar (UK), W. Fischbach (Germany), B. Flahou (Belgium), K.M. Fock (Singapore), A. Gasbarrini (Italy), G. Gasbarrini (Italy), G. Gensini (Italy), J. Gisbert (Spain), K.L. Goh (Malaysia), D.Y. Graham (USA), R. Herrero (France), R. Hunt (UK), E.J. Kuipers (The Netherlands), L. Kupcinskas (Kaunas), A. Lanas (Spain), M. Leja (Latvia), J.C. Machado (Portugal), V. Mahachai (Thailand), P. Malfertheiner (Germany), F. Megraud (France), T. Milosavljevic (Serbia), P. Moayyedi (Canada), J. Molina-Infante (Spain), Y. Niv (Israel), C. O'Morain (Ireland), A. Ristimaki (Finland), T. Rokkas (Greece), M. Rugge (Italy), M. Selgrad (Germany), S. Suerbaum (Germany), K. Sugano (Japan), B. Tepes (Slovenia), D. Vaira (Italy), M. Vieth (Germany), W. You (China).

  • Funding This study was supported by an unrestricted grant of Malesci/Menarini Foundation.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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