CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells

Gwenola Manic; Michele Signore; Antonella Sistigu; Giorgio Russo; Francesca Corradi; Silvia Siteni; Martina Musella; Sara Vitale; Maria Laura De Angelis; Matteo Pallocca; Carla Azzurra Amoreo; Francesca Sperati; Simone Di Franco; Sabina Barresi; Eleonora Policicchio; Gabriele De Luca; Francesca De Nicola; Marcella Mottolese; Ann Zeuner; Maurizio Fanciulli; Giorgio Stassi; Marcello Maugeri-Saccà; Marta Baiocchi; Marco Tartaglia; Ilio Vitale; Ruggero De Maria

doi:10.1136/gutjnl-2016-312623

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CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells

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Gwenola Manic Department of Biology, University of Rome “Tor Vergata”, Rome, Italy PubMed articles Google scholar articles
Michele Signore Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy PubMed articles Google scholar articles
Antonella Sistigu Department of Research, Advanced Diagnostics and Technological Innovation, Regina Elena National Cancer Institute, Rome, Italy PubMed articles Google scholar articles
Giorgio Russo Department of Research, Advanced Diagnostics and Technological Innovation, Regina Elena National Cancer Institute, Rome, Italy Institute of General Pathology, Catholic University and A. Gemelli Polyclinic, Rome, Italy PubMed articles Google scholar articles
Francesca Corradi Department of Biology, University of Rome “Tor Vergata”, Rome, Italy PubMed articles Google scholar articles
Silvia Siteni Department of Research, Advanced Diagnostics and Technological Innovation, Regina Elena National Cancer Institute, Rome, Italy Department of Science, University “Roma Tre”, Rome, Italy PubMed articles Google scholar articles
Martina Musella Department of Research, Advanced Diagnostics and Technological Innovation, Regina Elena National Cancer Institute, Rome, Italy Department of Molecular Medicine, University “La Sapienza”, Rome, Italy PubMed articles Google scholar articles
Sara Vitale Institute of General Pathology, Catholic University and A. Gemelli Polyclinic, Rome, Italy PubMed articles Google scholar articles
Maria Laura De Angelis Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy PubMed articles Google scholar articles
Matteo Pallocca SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, Rome Italy PubMed articles Google scholar articles
Carla Azzurra Amoreo Department of Pathology, Regina Elena National Cancer Institute, Rome, Italy PubMed articles Google scholar articles
Francesca Sperati Biostatistical Unit, Regina Elena National Cancer Institute, Rome, Italy PubMed articles Google scholar articles
Simone Di Franco Department of Surgical Oncological and Stomatological Sciences, University of Palermo, Palermo, Italy PubMed articles Google scholar articles
Sabina Barresi Genetics and Rare Diseases Research Division, Ospedale Pediatrico “Bambino Gesù”, Rome, Italy PubMed articles Google scholar articles
Eleonora Policicchio Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy Department of Experimental Medicine, University “La Sapienza”, Rome, Italy PubMed articles Google scholar articles
Gabriele De Luca Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy PubMed articles Google scholar articles
Francesca De Nicola SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, Rome Italy PubMed articles Google scholar articles
Marcella Mottolese Department of Pathology, Regina Elena National Cancer Institute, Rome, Italy PubMed articles Google scholar articles
Ann Zeuner Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy PubMed articles Google scholar articles
Maurizio Fanciulli SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, Rome Italy PubMed articles Google scholar articles
Giorgio Stassi Department of Surgical Oncological and Stomatological Sciences, University of Palermo, Palermo, Italy PubMed articles Google scholar articles
Marcello Maugeri-Saccà Division of Medical Oncology 2, Regina Elena National Cancer Institute, Rome, Italy PubMed articles Google scholar articles
Marta Baiocchi Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy PubMed articles Google scholar articles
Marco Tartaglia Genetics and Rare Diseases Research Division, Ospedale Pediatrico “Bambino Gesù”, Rome, Italy PubMed articles Google scholar articles
Ilio Vitale Department of Biology, University of Rome “Tor Vergata”, Rome, Italy Department of Research, Advanced Diagnostics and Technological Innovation, Regina Elena National Cancer Institute, Rome, Italy PubMed articles Google scholar articles
Ruggero De Maria Institute of General Pathology, Catholic University and A. Gemelli Polyclinic, Rome, Italy PubMed articles Google scholar articles

Correspondence to Dr Ilio Vitale, Department of Biology, University of Rome “Tor Vergata”, via della Ricerca Scientifica 1, Rome 00133, Italy; iliovit{at}gmail.com Professor Ruggero De Maria, Catholic University and Gemelli Polyclinic, Largo Francesco Vito 1, Rome 00168, Italy; ruggero.demaria{at}unicatt.it

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Citation

Manic G, Signore M, Sistigu A, et al

CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells

Gut 2018;67:903-917.

Publication history

Received July 15, 2016
Revised February 3, 2017
Accepted February 28, 2017
First published April 7, 2017.

Online issue publication

March 06, 2019

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