Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer

Ludovic Barault; Alessio Amatu; Giulia Siravegna; Agostino Ponzetti; Sebastian Moran; Andrea Cassingena; Benedetta Mussolin; Chiara Falcomatà; Alexandra M Binder; Carmen Cristiano; Daniele Oddo; Simonetta Guarrera; Carlotta Cancelliere; Sara Bustreo; Katia Bencardino; Sean Maden; Alice Vanzati; Patrizia Zavattari; Giuseppe Matullo; Mauro Truini; William M Grady; Patrizia Racca; Karin B Michels; Salvatore Siena; Manel Esteller; Alberto Bardelli; Andrea Sartore-Bianchi; Federica Di Nicolantonio

doi:10.1136/gutjnl-2016-313372

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Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer

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Ludovic Barault Department of Oncology, University of Torino, Torino, Italy Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy PubMed articles Google scholar articles
Alessio Amatu Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy PubMed articles Google scholar articles
Giulia Siravegna Department of Oncology, University of Torino, Torino, Italy Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy FIRC Institute of Molecular Oncology (IFOM), Milano, Italy PubMed articles Google scholar articles
Agostino Ponzetti Colorectal Cancer Unit, Medical Oncology Division 1, AOU Città della Salute e della Scienza, San Giovanni Battista Hospital, Turin, Italy PubMed articles Google scholar articles
Sebastian Moran Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L’Hospitalet, Barcelona, Spain PubMed articles Google scholar articles
Andrea Cassingena Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy PubMed articles Google scholar articles
Benedetta Mussolin Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy PubMed articles Google scholar articles
Chiara Falcomatà Department of Oncology, University of Torino, Torino, Italy Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy PubMed articles Google scholar articles
Alexandra M Binder Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA PubMed articles Google scholar articles
Carmen Cristiano Colorectal Cancer Unit, Medical Oncology Division 1, AOU Città della Salute e della Scienza, San Giovanni Battista Hospital, Turin, Italy PubMed articles Google scholar articles
Daniele Oddo Department of Oncology, University of Torino, Torino, Italy Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy PubMed articles Google scholar articles
Simonetta Guarrera Department of Medical Sciences, Italian Institute for Genomic Medicine – IIGM/HuGeF, University of Torino, Torino, Italy PubMed articles Google scholar articles
Carlotta Cancelliere Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy PubMed articles Google scholar articles
Sara Bustreo Colorectal Cancer Unit, Medical Oncology Division 1, AOU Città della Salute e della Scienza, San Giovanni Battista Hospital, Turin, Italy PubMed articles Google scholar articles
Katia Bencardino Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy PubMed articles Google scholar articles
Sean Maden Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articles Google scholar articles
Alice Vanzati FIRC Institute of Molecular Oncology (IFOM), Milano, Italy PubMed articles Google scholar articles
Patrizia Zavattari Department of Biomedical Sciences, Unit of Biology and Genetics, University of Cagliari, Cagliari, Italy PubMed articles Google scholar articles
Giuseppe Matullo Department of Medical Sciences, Italian Institute for Genomic Medicine – IIGM/HuGeF, University of Torino, Torino, Italy PubMed articles Google scholar articles
Mauro Truini Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy PubMed articles Google scholar articles
William M Grady Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA PubMed articles Google scholar articles
Patrizia Racca Colorectal Cancer Unit, Medical Oncology Division 1, AOU Città della Salute e della Scienza, San Giovanni Battista Hospital, Turin, Italy PubMed articles Google scholar articles
Karin B Michels Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA PubMed articles Google scholar articles
Salvatore Siena Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy PubMed articles Google scholar articles
Manel Esteller Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L’Hospitalet, Barcelona, Spain Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain PubMed articles Google scholar articles
Alberto Bardelli Department of Oncology, University of Torino, Torino, Italy Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy PubMed articles Google scholar articles
Andrea Sartore-Bianchi Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy PubMed articles Google scholar articles
Federica Di Nicolantonio Department of Oncology, University of Torino, Torino, Italy Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy PubMed articles Google scholar articles

Correspondence to Dr Ludovic Barault; ludovic.barault{at}unito.it and Federica Di Nicolantonio; federica.dinicolantonio{at}unito.it

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Citation

Barault L, Amatu A, Siravegna G, et al

Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer

Gut 2018;67:1995-2005.

Publication history

Received November 8, 2016
Revised August 18, 2017
Accepted August 21, 2017
First published October 5, 2017.

Online issue publication

April 03, 2019

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