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Early changes in the pharmacokinetic profile of vedolizumab-treated patients with IBD may predict response after dose optimisation
  1. Célia Gouynou1,
  2. Lieven Pouillon1,2,
  3. Hélène Rousseau3,
  4. Camille Zallot1,
  5. Cédric Baumann3,
  6. Laurent Peyrin-Biroulet1
  1. 1Department of Gastroenterology, Nancy University Hospital, Université de Lorraine, Vandœuvre-lès-Nancy, France
  2. 2Imelda GI Clinical Research Centre, Imeldaziekenhuis Bonheiden, Bonheiden, Belgium
  3. 3Clinical Research Support Facility PARC, UMDS Nancy University Hospital, Université de Lorraine, Vandœuvre-lès-Nancy, France
  1. Correspondence to Prof Laurent Peyrin-Biroulet, Inserm U954 and Department of Gastroenterology, Nancy University Hospital, Université de Lorraine, Lorraine 54 511, France; peyrinbiroulet{at}gmail.com

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We read with interest the recent paper by Colombel et al1 showing that vedolizumab is frequently used for patients with inflammatory bowel disease (IBD). There is evidence for an exposure–efficacy relationship for vedolizumab induction therapy.2 Increasing dosing frequency of vedolizumab to every 4 weeks leads to an improvement in clinical response in both ulcerative colitis (UC)3 and Crohn’s disease (CD).4 In contrast to anti-tumour necrosis factor (TNF) agents, the correlation between the response to dose optimisation and changes in the pharmacokinetic profile of vedolizumab-treated patients remains unknown. We performed a retrospective analysis of all vedolizumab-treated …

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