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Geographic variation in molecular subtype for gastric adenocarcinoma
  1. Ping Liao1,
  2. Feifei Jia1,2,
  3. Jamie K Teer3,
  4. Todd C Knepper2,
  5. Hong-Hao Zhou1,
  6. Yi-Jing He1,2,
  7. Howard L McLeod1,2
  1. 1 Hunan Key Laboratory of Pharmacogenetics, Department of Clinical Pharmacology, Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China
  2. 2 Moffitt Cancer Center, DeBartolo Family Personalized Medicine Institute, Tampa, Florida, USA
  3. 3 Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, USA
  1. Correspondence to Dr Yi-Jing He, Department of Clinical Pharmacology, XiangYa Hospital, Central South University, Changsha, Hunan, China; yijing.he{at}moffitt.org and Prof Howard L McLeod, Moffitt Cancer Center, DeBartolo Family Personalized Medicine Institute, Tampa, FL 33612, USA; Howard.McLeod{at}moffitt.org

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The presence of distinct molecular subgroups of gastric cancer (GC) has been recently highlighted in Gut.1 2 However, there has been little focus on the geographic distribution of molecular subgroups. Differences in GC molecular subtypes were assessed using data from The Cancer Genome Atlas (TCGA). Razvan et al established four clinically relevant molecular subtypes, which are MSS (microsatellite stable)/TP53−, MSS/TP53+, MSI (microsatellite instability) and MSS/EMT (epithelial–mesenchymal transition), further delineating GC.3 The clinical significance has been evaluated in a recent study using the TCGA proposed comprehensive molecular classification of patients with GC into four subtypes: Epstein-Barr virus (EBV), chromosomal instability (CIN), MSI and genomically stable (GS). Sohn et al reported that CIN and MSI subtypes had better overall survival than GS, but worse than EBV subtypes.4 Identification of molecular subtypes of GC may offer improved ways to monitor the progression, and predict prognosis …

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